Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125
 
  • Details

Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125

Journal
Annals of hematology
Journal Volume
100
Journal Issue
2
Pages
487 - 498
Date Issued
2021-02
Author(s)
Wang, Yu-Hung
CHIEN-CHIN LIN  
CHIA-LANG HSU  
SHENG-YU HUNG  
CHI-YUAN YAO  
Lee, Sze-Hwei
CHENG-HONG TSAI  
HSIN-AN HOU  
WEN-CHIEN CHOU  
HWEI-FANG TIEN  
DOI
10.1007/s00277-020-04358-y
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/544543
Abstract
Expression of long non-coding RNA KIAA0125 has been incorporated in various gene expression signatures for prognostic prediction in acute myeloid leukemia (AML) patients, yet its functions and clinical significance remain unclear. This study aimed to investigate the clinical and biological characteristics of AML bearing different levels of KIAA0125. We profiled KIAA0125 expression levels in bone marrow cells from 347 de novo AML patients and found higher KIAA0125 expression was closely associated with RUNX1 mutation, but inversely correlated with t(8;21) and t(15;17) karyotypes. Among the 227 patients who received standard chemotherapy, those with higher KIAA0125 expression had a lower complete remission rate, shorter overall survival (OS) and disease-free survival (DFS) than those with lower expression. The prognostic significance was validated in both TCGA and GSE12417 cohorts. Subgroup analyses showed that higher KIAA0125 expression also predicted shorter DFS and OS in patients with normal karyotype or non-M3 AML. In multivariable analysis, higher KIAA0125 expression remained an adverse risk factor independent of age, WBC counts, karyotypes, and mutation patterns. Bioinformatics analyses revealed that higher KIAA0125 expression was associated with hematopoietic and leukemic stem cell signatures and ATP-binding cassette transporters, two predisposing factors for chemoresistance.
Subjects
Acute myeloid leukemia; Chemoresistance; KIAA0125; Leukemic stem cell signatures; Long non-coding RNA
SDGs

[SDGs]SDG3

Other Subjects
ABC transporter; cytarabine; idarubicin; long untranslated RNA; transcription factor RUNX1; long untranslated RNA; RNA; acute myeloid leukemia; adolescent; adult; aged; aging; Article; bioinformatics; bone marrow cell; cancer chemotherapy; cancer prognosis; cohort analysis; controlled study; disease free survival; drug megadose; drug resistance; female; gene expression; gene mutation; genetic association; hematopoietic stem cell; human; human cell; karyotype; KIAA0125 gene; leukemia remission; leukocyte count; major clinical study; male; overall survival; pathogenesis; priority journal; risk factor; RUNX1 gene; tumor suppressor gene; acute myeloid leukemia; biosynthesis; clinical trial; gene expression regulation; metabolism; middle aged; mortality; survival rate; very elderly; Adolescent; Adult; Aged; Aged, 80 and over; Disease-Free Survival; Female; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; RNA, Long Noncoding; RNA, Neoplasm; Survival Rate
Publisher
SPRINGER
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science