https://scholars.lib.ntu.edu.tw/handle/123456789/545311
標題: | Immunocompetent nontransgenic mouse models for studying hepatitis B virus immune responses | 作者: | Tzeng H.-T. PING-NING HSU PEI-JER CHEN |
公開日期: | 2013 | 出版社: | Blackwell Publishing | 卷: | 28 | 期: | SUPPL 1 | 起(迄)頁: | 116-119 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Although the chronicity of hepatitis B virus (HBV) infection is the result of impaired HBV-specific immune responses that cannot eliminate or clear the infected hepatocytes efficiently, many issues remained unsettled. It is thus crucial to have a suitable laboratory animal to study the immunopathogenesis of HBV infection and the mechanisms of HBV persistence. To meet the requirement of a mouse model resembling natural chronic HBV infection in human, there are several approaches in the development of mouse animal model by using hydrodynamic-based transfection of HBV DNA, delivery of adenovirus or adeno-associated viral vectors containing HBV DNA for studying HBV immune responses. These immunocompetent nontransgenic mouse animal models will provide new approaches to investigate the mechanisms of immune pathogenesis in HBV infection. ? 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984577973&doi=10.1111%2fjgh.12035&partnerID=40&md5=dc39f80f12372bc2d13ac8d0ae18145e https://scholars.lib.ntu.edu.tw/handle/123456789/545311 |
ISSN: | 0815-9319 | DOI: | 10.1111/jgh.12035 | SDG/關鍵字: | adenovirus vector; CXCL3 chemokine; gamma interferon inducible protein 10; granulocyte colony stimulating factor; hepatitis B core antigen; interleukin 12; interleukin 6; monocyte chemotactic protein 1; RANTES; small interfering RNA; virus DNA; adaptive immunity; antibody production; cytokine production; gene expression; hepatitis B; Hepatitis B virus; human; immune response; immunopathogenesis; innate immunity; liver cell; liver cell carcinoma; liver tumor; nonhuman; priority journal; review; viral clearance; virion; virus genome |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。