Immunocompetent nontransgenic mouse models for studying hepatitis B virus immune responses
Journal
Journal of Gastroenterology and Hepatology (Australia)
Journal Volume
28
Journal Issue
SUPPL 1
Pages
116-119
Date Issued
2013
Author(s)
Abstract
Although the chronicity of hepatitis B virus (HBV) infection is the result of impaired HBV-specific immune responses that cannot eliminate or clear the infected hepatocytes efficiently, many issues remained unsettled. It is thus crucial to have a suitable laboratory animal to study the immunopathogenesis of HBV infection and the mechanisms of HBV persistence. To meet the requirement of a mouse model resembling natural chronic HBV infection in human, there are several approaches in the development of mouse animal model by using hydrodynamic-based transfection of HBV DNA, delivery of adenovirus or adeno-associated viral vectors containing HBV DNA for studying HBV immune responses. These immunocompetent nontransgenic mouse animal models will provide new approaches to investigate the mechanisms of immune pathogenesis in HBV infection. ? 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
SDGs
Other Subjects
adenovirus vector; CXCL3 chemokine; gamma interferon inducible protein 10; granulocyte colony stimulating factor; hepatitis B core antigen; interleukin 12; interleukin 6; monocyte chemotactic protein 1; RANTES; small interfering RNA; virus DNA; adaptive immunity; antibody production; cytokine production; gene expression; hepatitis B; Hepatitis B virus; human; immune response; immunopathogenesis; innate immunity; liver cell; liver cell carcinoma; liver tumor; nonhuman; priority journal; review; viral clearance; virion; virus genome
Publisher
Blackwell Publishing
Type
review