Rather than interleukin-27, interleukin-6 expresses positive correlation with liver severity in naïve hepatitis B infection patients
Journal
Liver International
Journal Volume
32
Journal Issue
6
Pages
928-936
Date Issued
2012
Author(s)
Kao J.-T.
Lai H.-C.
Tsai S.-M.
Lin P.-C.
Chuang P.-H.
Yu C.-J.
Cheng K.-S.
Su W.-P.
Peng C.-Y.
Wu Y.-Y.
Abstract
Aims: Effective cytokines can drive the commitment of naive T cells to regulate immune response after antigen-mediated activation. Aims are to elucidate the clinical role of serum IL-27 and IL-6 in the different stages of na?ve hepatitis B virus (HBV)-infected patients. Methods: Samples with well-characterized clinical profiles were assessed from 395 HBV-infected patients including chronic hepatitis B (CHB) group in 291 patients, liver cirrhosis (LC) group in 57 patients, hepatocellular carcinoma (HCC) group in 47 patients. Another 139 non-HBV infected individuals were enrolled as control group (CG) including 104 with normal liver function (NF) and 35 with liver dysfunction (LD). Results: The HBV-infected group and separated groups presented significantly higher IL-27 and IL-6 expression than the CG or subgroups of CG. In contrast to IL-27, IL-6 showed significant differences with deteriorating liver condition compared with LC or HCC with CHB groups. Furthermore, IL-6, rather than IL-27, showed significant statistical differences in patients with advanced liver disease compared with those of mild or moderate to severe liver disease and in patients with terminal stage HCC compared with those of early to intermediate or advanced stage HCC. The data associated with liver function, including Albumin, Bilirubin, INR, Platelet and AFP levels, were significantly correlated to IL-6 expression, but had weak correlation to IL-27 expression in HBV patients. Conclusion: Serum IL-27 can trigger immune response to prevent hepatic injury in different clinical-pathologic stages of HBV-infected patients earlier, but IL-6 may play an extremely important role to determine the liver progression. ? 2012 John Wiley & Sons A/S.
Subjects
Cytokines; Hepatitis B virus-infected patients; Hepatocellular carcinoma; Interleukin-27/interleukin-6; Liver cirrhosis
SDGs
Other Subjects
albumin; alpha fetoprotein; bilirubin; interleukin 27; interleukin 6; albumin blood level; article; bilirubin blood level; cancer staging; controlled study; disease association; disease severity; hepatitis B; human; human tissue; international normalized ratio; liver cell carcinoma; liver cirrhosis; liver failure; liver function; major clinical study; protein blood level; protein expression; thrombocyte count; Adolescent; Adult; Aged; Aged, 80 and over; Biological Markers; Carcinoma, Hepatocellular; Case-Control Studies; Disease Progression; Female; Hepatitis B, Chronic; Humans; Interleukin-6; Interleukins; Liver; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Predictive Value of Tests; Severity of Illness Index; Taiwan; Young Adult
Type
journal article