https://scholars.lib.ntu.edu.tw/handle/123456789/545321
標題: | Galectin-3 gene (LGALS3) +292C allele is a genetic predisposition factor for rheumatoid arthritis in Taiwan | 作者: | CHUNG-YI HU Chang S.-K. Wu C.-S. Tsai W.-I. PING-NING HSU |
公開日期: | 2011 | 卷: | 30 | 期: | 9 | 起(迄)頁: | 1227-1233 | 來源出版物: | Clinical Rheumatology | 摘要: | Galectin-3 is a beta-galactoside-binding lectin which is involved in modulating inflammation and apoptosis. Elevated expression of galectin-3 has been demonstrated in synovium of rheumatoid arthritis (RA). The aim of our study is to investigate the genetic polymorphisms of galectin-3 in association with RA. Polymorphisms of galectin-3 gene (LGALS3) were compared between 151 RA patients and 182 healthy subjects in Taiwan. Variants at two LGALS3 single nucleotide polymorphism (SNP) sites (rs4644 and rs4652, corresponding to LAGLS3 +191 and +292) were genotyped by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) and sequence-specific oligonucleotide probe hybridization, respectively. The allelic carriage of LGALS3 +292C was increased in patients with RA (66.9% in RA vs. 52.7% in controls, odds ratio=1.8, 95% confidence interval=1.2-2.8, p=0.009). These results implicate that the genetic polymorphisms in galectin-3 gene may contribute to development of RA. ? 2011 Clinical Rheumatology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052623499&doi=10.1007%2fs10067-011-1741-2&partnerID=40&md5=feb10eca61892b035d8a4626f3f305b1 https://scholars.lib.ntu.edu.tw/handle/123456789/545321 |
ISSN: | 0770-3198 | DOI: | 10.1007/s10067-011-1741-2 | SDG/關鍵字: | alanine aminotransferase; aspartate aminotransferase; creatinine; galectin 3; methotrexate; tumor necrosis factor alpha inhibitor; adult; allele; article; blood sampling; controlled study; enzyme linked immunosorbent assay; female; gene frequency; gene identification; genetic association; genetic predisposition; genetic susceptibility; genetic variability; genotype; haplotype; human; hybridization; major clinical study; male; oligonucleotide probe; polymerase chain reaction; priority journal; protein expression; restriction fragment length polymorphism; rheumatoid arthritis; sequence specific oligonucleotide probe hybridization; single nucleotide polymorphism; Taiwan; Arthritis, Rheumatoid; Female; Galectin 3; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Nucleic Acid Hybridization; Oligonucleotide Probes; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Taiwan |
顯示於: | 醫學系 |
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