https://scholars.lib.ntu.edu.tw/handle/123456789/545340
Title: | Helicobacter pylori infection and the risk of gastric malignancy | Authors: | Hsu P.-I. Lai K.-H. PING-NING HSU Lo G.-H. Yu H.-C. Chen W.-C. Tsay F.-W. Lin H.-C. Tseng H.-H. Ger L.-P. Chen H.-C. |
Issue Date: | 2007 | Journal Volume: | 102 | Journal Issue: | 4 | Start page/Pages: | 725-730 | Source: | American Journal of Gastroenterology | Abstract: | OBJECTIVE: This prospective cohort study investigated the impact of Helicobacter pylori infection on the development of various gastric malignancies. METHODS: We prospectively followed up 1,225 dyspeptic Taiwanese who had nonulcer dyspepsia, gastric ulcers, or duodenal ulcers at enrollment. Among them, 618 (50.4%) had H. pylori infection and 607 (49.6%) did not. Patients underwent endoscopy at enrollment and at 1- to 3-yr intervals thereafter. RESULTS: During a mean follow-up of 6.3 yr, gastric adenocarcinoma developed in 7 of the 618 H. pylori-infected patients, but in none of the 607 uninfected patients (1.1% vs 0.0%, P = 0.015). The incidence of gastric lymphoma was 0.2% (1/618) and 0% in H. pylori-infected and uninfected patients. Taken together, the development rate of gastric malignancy in H. pylori-infected patients was significantly higher than that in uninfected patients (1.3% vs 0%, P = 0.007). Among H. pylori-infected subjects, the incidence of gastric malignancy was similar between those receiving and not receiving eradication therapy (1.4% vs 1.2%). Multivariate analysis showed that intestinal metaplasia was the only independent factor predicting subsequent development of gastric malignancy in H. pylori-infected subjects with an odds ratio of 4.5 (95% CI 1.1-19.1). CONCLUSIONS: In this prospective cohort study, all gastric malignancies, including adenocarcinoma and lymphoma, developed in H. pylori-infected patients. The finding implies that H. pylori is a necessary cause of most gastric malignancies. Follow-up for H. pylori-infected patients who have intestinal metaplasia is indicated. ? 2007 by Am. Coll. of Gastroenterology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33947640081&doi=10.1111%2fj.1572-0241.2006.01109.x&partnerID=40&md5=b2971051283f81c56024661d86155f3f https://scholars.lib.ntu.edu.tw/handle/123456789/545340 |
ISSN: | 0002-9270 | DOI: | 10.1111/j.1572-0241.2006.01109.x | SDG/Keyword: | adult; aged; article; cancer incidence; cancer risk; controlled study; duodenum ulcer; dyspepsia; eradication therapy; female; follow up; gastrointestinal biopsy; Helicobacter infection; Helicobacter pylori; human; human tissue; intestine metaplasia; major clinical study; male; multivariate analysis; priority journal; prospective study; stomach adenocarcinoma; stomach lymphoma; stomach ulcer; Adenocarcinoma; Chi-Square Distribution; Endoscopy, Gastrointestinal; Female; Helicobacter Infections; Helicobacter pylori; Humans; Incidence; Logistic Models; Male; Middle Aged; Prospective Studies; Risk Factors; Stomach Neoplasms; Taiwan [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
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