https://scholars.lib.ntu.edu.tw/handle/123456789/545364
標題: | Impact of Helicobacter pylori eradication on the development of MALT, gland atrophy and intestinal metaplasia of the antrum | 作者: | Hsu P.-I. Lai K.-H. Tseng H.-H. Lin C.-K. Lo G.-H. Cheng J.-S. Chan H.-H. Hsu J.-H. Jou H.-S. Ger L.-P. Chen W. PING-NING HSU |
關鍵字: | Gland atrophy; Helicobacter pylori; Intestinal metaplasia; Mucosa- associated lymphoid tissue | 公開日期: | 2000 | 卷: | 63 | 期: | 4 | 起(迄)頁: | 279-287 | 來源出版物: | Chinese Medical Journal (Taipei) | 摘要: | Background. Chronic Helicobacter pylori infection leads to the development of mucosa-associated lymphoid tissue (MALT), gland atrophy, intestinal metaplasia, and in certain individuals, gastric lymphoma and adenocarcinoma. We conducted a prospective study to determine the effect of H pylori eradication on the development of MALT, gland atrophy and intestinal metaplasia. Methods. From July 1995 to October 1996, 63 consecutive patients with H pylori-associated peptic ulcer disease were enrolled in a bacterial eradication trial. The grade of MALT and the degree of gastritis of the antrum were assessed using Wotherspoon's scale and the Sydney system before treatment, and at eight weeks and one year after H pylori eradication therapy. Results: During the study period, 43 patients received complete follow-up. In the patient group with eradication failure (n = 22), MALT score was significantly decreased at the end of the eighth week (p < 0.05) but returned to the initial level by one year of follow-up. There were no changes in the scores for inflammation, neutrophil activity, gland atrophy or intestinal metaplasia at the end of the eighth week and at one year following H pylori eradication therapy. In contrast, there was a marked reduction in the MALT, inflammation, and activity scores at eight weeks (p < 0.01, < 0.05 and < 0.05, respectively) and one year after treatment (p < 0.05, < 0.001 and < 0.001, respectively) in the patient group with successful eradication (n = 21). However, no significant changes in gland atrophy and intestinal metaplasia were observed during the follow-up period. Conclusions. Eradication of H pylori leads to regression of MALT in the stomach, but the degrees of gland atrophy and intestinal metaplasia remain unchanged, even after one-year of follow-up. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-6744224409&partnerID=40&md5=927023c9f65366cb41e5094e79ed3f48 https://scholars.lib.ntu.edu.tw/handle/123456789/545364 |
ISSN: | 0578-1337 | SDG/關鍵字: | ampicillin; lansoprazole; metronidazole; tetracycline; adult; aged; article; clinical article; controlled study; eradication therapy; female; follow up; gastritis; gastrointestinal endoscopy; Gram negative infection; Helicobacter pylori; human; intestine metaplasia; male; neutrophil; peptic ulcer; prospective study; stomach antrum; stomach biopsy; stomach mucosa; Adult; Aged; Atrophy; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Lymphoid Tissue; Male; Metaplasia; Middle Aged; Pyloric Antrum |
顯示於: | 醫學系 |
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