https://scholars.lib.ntu.edu.tw/handle/123456789/545377
標題: | Serum pepsinogen as a predictor for gastric cancer death A 16-year community-based cohort study | 作者: | TSUNG-HSIEN CHIANG Chiu S.Y.-H. Chen S.L.-S. Yen A.M.-F. Fann J.C.-Y. Liu C.-Y. Chou C.-K. HAN-MO CHIU CHIA-TUNG SHUN MING-SHIANG WU Lin J.-T. YI-CHIA LEE Chen, Tony Hsiu Hsi Lin M.-W. |
公開日期: | 2019 | 出版社: | Lippincott Williams and Wilkins | 卷: | 53 | 期: | 5 | 起(迄)頁: | E186-E193 | 來源出版物: | Journal of Clinical Gastroenterology | 摘要: | Goals: The purpose of this article is to validate the long-term association between initial serum pepsinogen (PG) measurements and subsequent gastric cancer-specific deaths from a long-term longitudinal cohort. Background: Endoscopic surveillance can be effective and efficient in reducing gastric cancer mortality if a biomarker such as serum PG is available to identify high-risk individuals and if the biomarker also is specific to gastric cancer risk. Study: Between 1995 and 1998, a gastric cancer-screening program was conducted in a high-risk population: The first stage involved PG testing, and the second stage involved upper endoscopy. The outcome was gastric cancer death, which was monitored until December 31, 2010; results were expressed as the hazard ratio (HR) and corresponding 95% confidence interval (CI) using the Cox proportional hazards regression model. Other causes of death were used as comparators. Results: Among participants (n=3514) aged ?30 years, 1682 (47.9%) were screened to determine serum PG levels. After 16 years of followup, 14 deaths from gastric cancer were documented. Multivariate analyses adjusted for age, sex, and Helicobacter pylori serological positivity showed that PG-I <30 μg/L and PG-I <30 μg/L or PG-I/II ratio <3 were significantly associated with the risk of gastric cancer death (HR, 3.27; 95% CI, 1.11-9.61 and HR, 3.45; 95% CI, 1.18-10.12, respectively). In contrast, there were no significant associations between PG and other causes of death, including neoplastic and non-neoplastic diseases. Conclusion: This long-term cohort study shows the usefulness of PG measurement as a biomarker that is specific to the risk of gastric cancer death. Copyright ? 2019 World Gastroenterology Organisation. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041600049&doi=10.1097%2fMCG.0000000000000992&partnerID=40&md5=74a1703bc60dadb80c993f0afe003a24 https://scholars.lib.ntu.edu.tw/handle/123456789/545377 |
ISSN: | 0192-0790 | DOI: | 10.1097/MCG.0000000000000992 | SDG/關鍵字: | pepsinogen; pepsinogen; tumor marker; adult; Article; cancer mortality; cancer risk; cohort analysis; eradication therapy; female; follow up; high risk population; human; longitudinal study; major clinical study; male; mortality rate; mortality risk; priority journal; protein blood level; stomach cancer; aged; blood; middle aged; mortality; predictive value; stomach tumor; Taiwan; very elderly; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cohort Studies; Female; Humans; Male; Middle Aged; Pepsinogen A; Predictive Value of Tests; Stomach Neoplasms; Taiwan |
顯示於: | 醫學系 |
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