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  4. Timing and risk factors for a positive fecal immunochemical test in subsequent screening for colorectal neoplasms
 
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Timing and risk factors for a positive fecal immunochemical test in subsequent screening for colorectal neoplasms

Journal
PLoS ONE
Journal Volume
10
Journal Issue
9
Date Issued
2015
Author(s)
TSUNG-HSIEN CHIANG  
YI-CHIA LEE  
Liao W.-C.
Chung J.-H.
HAN-MO CHIU  
CHIA-HUNG TU  
Chen S.-C.
MING-SHIANG WU  
DOI
10.1371/journal.pone.0136890
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947465879&doi=10.1371%2fjournal.pone.0136890&partnerID=40&md5=f193c3b67f6fe29c30e337f812fc7376
https://scholars.lib.ntu.edu.tw/handle/123456789/545384
Abstract
Background: Following a negative test, the performance of fecal immunochemical testing in the subsequent screening round is rarely reported. It is crucial to allocate resources to participants who are more likely to test positive subsequently following an initial negative result. Objective: To identify risk factors associated with a positive result in subsequent screening. Methods: Dataset was composed of consecutive participants who voluntarily underwent fecal tests and colonoscopy in a routine medical examination at the National Taiwan University Hospital between January 2007 and December 2011. Risk factor assessment of positive fecal test in subsequent screening was performed by using the Cox proportional hazards models. Results: Our cohort consisted of 3783 participants during a 5-year period. In three rounds of subsequent testing, 3783, 1537, and 624 participants underwent fecal tests, respectively; 5.7%, 5.1%, and 3.9% tested positive, respectively, and the positive predictive values were 40.2%, 20.3%, and 20.8%, respectively. Age ?60 years (adjusted hazard ratio: 1.53, 95% CI: 1.21-1.93) and male gender (1.32, 95% CI: 1.02-1.69) were risk factors; however, an interaction between age and gender was noted. Men had higher risk than women when they were <60 years of age (p = 0.002), while this difference was no longer observed when ?60 years of age (p = 0.74). The optimal interval of screening timing for participant with baseline negative fecal test was 2 years. Conclusions: Following a negative test, older age and male gender are risk factors for a positive result in the subsequent rounds while the gender difference diminishes with age. Biennial screening is sufficient following a negative fecal test. ? 2015 Chiang et al.
SDGs

[SDGs]SDG3

Other Subjects
antithrombocytic agent; glucose; tumor marker; adult; age distribution; Article; cancer risk; cancer screening; colonoscopy; colorectal cancer; controlled study; drug use; feces analysis; female; glucose blood level; human; hypertension; immunohistochemistry; major clinical study; male; metabolic syndrome X; predictive value; risk assessment; risk factor; sex difference; age; chemistry; cohort analysis; colon; Colorectal Neoplasms; early cancer diagnosis; feces; immunochemistry; mass screening; middle aged; pathology; proportional hazards model; rectum; Taiwan; Age Factors; Biomarkers, Tumor; Cohort Studies; Colon; Colonoscopy; Colorectal Neoplasms; Early Detection of Cancer; Feces; Female; Humans; Immunochemistry; Male; Mass Screening; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Rectum; Risk Factors; Sex Factors; Taiwan
Publisher
Public Library of Science
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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