|Title:||Performance of the immunochemical fecal occult blood test in predicting lesions in the lower gastrointestinal tract||Authors:||TSUNG-HSIEN CHIANG
|Issue Date:||2011||Publisher:||Canadian Medical Association||Journal Volume:||183||Journal Issue:||13||Start page/Pages:||1474-1481||Source:||CMAJ||Abstract:||
Background: Previous studies have suggested that the immunochemical fecal occult blood test has superior specificity for detecting bleeding in the lower gastrointestinal tract even if bleeding occurs in the upper tract. We conducted a large population-based study involving asymptomatic adults in Taiwan, a population with prevalent upper gastro - intestinal lesions, to confirm this claim. Methods: We conducted a prospective cohort study involving asymptomatic people aged 18 years or more in Taiwan recruited to undergo an immunochemical fecal occult blood test, colonoscopy and esophagogastroduodenos - copy between August 2007 and July 2009. We compared the prevalence of lesions in the lower and upper gastrointestinal tracts be - tween patients with positive and negative fecal test results. We also identified risk factors associated with a false- positive fecal test result. Results: Of the 2796 participants, 397 (14.2%) had a positive fecal test result. The sensitivity of the test for predicting lesions in the lower gastrointestinal tract was 24.3%, the specificity 89.0%, the positive predictive value 41.3%, the negative predictive value 78.7%, the positive likelihood ratio 2.22, the negative likelihood ratio 0.85 and the accuracy 73.4%. The prevalence of lesions in the lower gastrointestinal tract was higher among those with a positive fecal test result than among those with a negative result (41.3% v. 21.3%, p < 0.001). The prevalence of lesions in the upper gastrointestinal tract did not differ significantly between the two groups (20.7% v. 17.5%, p = 0.12). Almost all of the participants found to have colon cancer (27/28, 96.4%) had a positive fecal test result; in contrast, none of the three found to have esophageal or gastric cancer had a positive fecal test result (p < 0.001). Among those with a negative finding on colonos copy, the risk factors associated with a false-positive fecal test result were use of anti platelet drugs (adjusted odds ratio [OR] 2.46, 95% confidence interval [CI] 1.21-4.98) and a low hemoglobin concentration (ad justed OR 2.65, 95% CI 1.62-4.33). Interpretation: The immunochemical fecal occult blood test was specific for predicting lesions in the lower gastro intestinal tract. However, the test did not adequately predict lesions in the upper gastrointestinal tract. ? 2011 Canadian Medical Association or its licensors.
|ISSN:||0820-3946||DOI:||10.1503/cmaj.101248||metadata.dc.subject.other:||antithrombocytic agent; hemoglobin; adult; aged; article; colon adenoma; colon cancer; colonoscopy; colorectal adenoma; colorectal cancer; controlled clinical trial; controlled study; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; drug use; esophagogastroduodenoscopy; esophagus cancer; false positive result; female; Helicobacter infection; hemoglobin blood level; human; immunohistochemistry; intestine injury; lower gastrointestinal tract lesion; major clinical study; male; occult blood test; population research; predictive value; prognosis; risk assessment; screening test; sensitivity and specificity; stomach cancer
|Appears in Collections:||醫學系|
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