Multiphoton imaging of the toxic effect of carbon tetrachloride on hepatobiliary metabolism in vivo
Journal
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Journal Volume
10859
Date Issued
2019
Author(s)
Huang H.-C., Lin C.-J., Lee S.-L., Lee H.-S., Dong C.-Y.
Lin C.-J.
Lee S.-L.
Abstract
We used intravital multiphoton microscopy to study the recovery of hepatobiliary metabolism following carbon tetrachloride (CCl4) induced hepatotoxicity in mouse. Our images were processed by a first order kinetic model to generate rate constant resolved images of the mouse liver. At Day 14 following induction, a restoration of the mouse hepatobiliary function was found. Our approach allows the study of the response of hepatic functions to chemical agents in real time and is useful for studying pharmacokinetics of drug molecules through optical microscopic imaging.
SDGs
Publisher
SPIE
Type
conference paper