https://scholars.lib.ntu.edu.tw/handle/123456789/545712
標題: | Hepatocellular carcinoma with duodenal invasion and metastasis | 作者: | JA-DER LIANG CHIEN-HUNG CHEN SHIH-JER HSU JIN-CHUAN SHEU PEI-MING YANG Lee, Hsuan-Shu Lee, Cha-Ze GUAN-TARN HUANG |
公開日期: | 2012 | 出版社: | Blackwell Publishing | 卷: | 27 | 期: | 4 | 起(迄)頁: | 677-683 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background and Aim: Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths in Taiwan. HCC with duodenal involvement are rare and are associated with a poor prognosis. The purpose of this retrospective study was to collect clinical information and data regarding survival following various treatments. Methods: Between 1996 and 2009, 21 cases (17 men) were diagnosed with HCC and duodenal invasion and metastases by diagnostic imaging, endoscopy with biopsy, or surgically collected specimens sent to pathology. The clinical course was analyzed from the patients' medical records. Results: Gastrointestinal bleeding was reported in 18/21 patients. Diagnostic imaging showed that the majority of cases involved direct tumor invasion (predominantly from the right liver lobe) and six cases from metastasis. Tumor mass and ulcerations were the most common features noted on endoscopy. In addition to the component therapy and medication treatment, panendoscopic hemostasis, surgery, transcatheter arterial embolization, and radiotherapy were performed for the management of duodenal involvement and gastrointestinal bleeding. Survival duration after duodenal involvement ranged from 0.2 to 57.8months (mean 10.5months). Conclusions: Gastrointestinal bleeding in advanced HCC should raise suspicions of duodenal involvement. HCC can involve the duodenum by direct invasion (from either the left or right liver lobes) or metastasis. The prognosis for HCC patients with duodenal involvement is poor, but is improved by supportive care and application of various treatment modalities. ? 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863360657&doi=10.1111%2fj.1440-1746.2011.06869.x&partnerID=40&md5=c1457b4e75ad2e54eeb4ab2d45494754 https://scholars.lib.ntu.edu.tw/handle/123456789/545712 |
ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.2011.06869.x | SDG/關鍵字: | adult; aged; article; artificial embolism; cancer invasion; cancer prognosis; cancer radiotherapy; cancer survival; clinical article; duodenum disease; duodenum metastasis; endoscopy; female; gastrointestinal hemorrhage; human; liver cell carcinoma; liver resection; male; medical record review; metastasis; priority journal; radiofrequency ablation; retrospective study |
顯示於: | 醫學系 |
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