https://scholars.lib.ntu.edu.tw/handle/123456789/545820
Title: | The association between gastro-oesophageal reflux disease and subsequent rheumatoid arthritis occurrence: A nested case-control study from Taiwan | Authors: | Lin H.-C. Xirasagar S. Lee, Cha-Ze Huang C.-C. Chen C.-H. |
Keywords: | epidemiology; gastroesophageal reflux disease; rheumatoid arthritis | Issue Date: | 2017 | Publisher: | BMJ Publishing Group | Journal Volume: | 7 | Journal Issue: | 11 | Source: | BMJ Open | Abstract: | Objective Gastro-oesophageal reflux disease (GORD) is a common comorbidity among patients with rheumatoid arthritis (RA). While GORD has been attributed to the antirheumatic medications, no studies of human cohorts have investigated a link between GORD and RA. This study investigates whether GORD is associated with a subsequent RA diagnosis over a 5-year follow-up using a population-based dataset. Setting Taiwan Participants We used data from the Taiwan Longitudinal Health Insurance Database. The study group consisted of 13 645 patients with an ambulatory claim showing a GORD diagnosis. We used propensity score matching to select 13 645 comparison patients (one per study patient with GORD). Intervention We tracked each patient's claims over a 5-year period to identify those who subsequently received a diagnosis of RA. Cox proportional hazard (PH) regression modelling was used for analysis. Results Over 5-year follow-up, RA incidence rate per 1000 person-years was 2.81 among patients with GORD and 0.84 among the comparison group. Cox PH modelling showed that GORD was independently associated with a 2.84-fold increased risk of RA (95% CI 2.09 to 3.85) over 5-year follow-up, after adjusting for the number of ambulatory care visits within the year following the index date (to mitigate surveillance bias). Conclusions We observed that GORD might associate with subsequent RA occurrence. Because current treatment guidelines for RA emphasise early diagnosis and prompt treatment, the observed association between GORD and RA may help acquaint clinicians to patients with GORD with higher RA risk and facilitate early diagnosis and treatment. ? 2017 Article author(s) (or their employer(s) unless otherwise stated in the text of the article). All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049410799&doi=10.1136%2fbmjopen-2017-016667&partnerID=40&md5=f87b09a4cadc55a1d75b576bce029ef4 https://scholars.lib.ntu.edu.tw/handle/123456789/545820 |
ISSN: | 2044-6055 | DOI: | 10.1136/bmjopen-2017-016667 | SDG/Keyword: | proton pump inhibitor; adult; ambulatory care; Article; case control study; comorbidity; early diagnosis; female; follow up; gastroesophageal reflux; human; incidence; major clinical study; male; prescription; propensity score; rheumatoid arthritis; Taiwan; aged; complication; gastroesophageal reflux; middle aged; proportional hazards model; rheumatoid arthritis; Adult; Aged; Arthritis, Rheumatoid; Case-Control Studies; Comorbidity; Female; Gastroesophageal Reflux; Humans; Incidence; Male; Middle Aged; Propensity Score; Proportional Hazards Models; Taiwan [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.