https://scholars.lib.ntu.edu.tw/handle/123456789/545823
標題: | A case-control study of the association between ulcerative colitis and hyperthyroidism in an Asian population | 作者: | Tsai M.-C. Lin H.-C. Lee, Cha-Ze |
公開日期: | 2017 | 出版社: | Blackwell Publishing Ltd | 卷: | 86 | 期: | 6 | 起(迄)頁: | 825-829 | 來源出版物: | Clinical Endocrinology | 摘要: | Objective: Ulcerative colitis (UC) is a chronic relapsing inflammatory disease with significant clinical diversity. However, the aetiology, pathogenesis and optimal treatment of UC remain unclear. The purpose of this case-control study was to investigate the association between previously diagnosed hyperthyroidism and UC using a large population-based data set in Taiwan. Methods: The data for this population-based case-control study were retrieved from the Taiwan Longitudinal Health Insurance Database 2005. We included 2709 patients with UC as cases and 8127 sex- and age-matched patients without UC as controls. A conditional logistic regression analysis was conducted to compute the odds ratio (OR) and corresponding 95% confidence interval (CI) for the association between UC and prior hyperthyroidism. Results: We found that, in total, 327 of the 10?836 sampled patients (3.02%) had previously been diagnosed with hyperthyroidism. There was a higher proportion of prior hyperthyroidism among cases than controls (4.10% vs 2.66%, P<.001). A conditional logistic regression showed that the OR of prior hyperthyroidism was 1.57 (95% CI=1.24-1.98) compared to controls. Similarly, after adjusting for monthly income, geographic location and urbanization level, cases were still more likely to have previously been diagnosed with hyperthyroidism than controls (OR=1.61, 95% CI=1.27-2.05). Furthermore, we analysed the ORs of prior hyperthyroidism between cases and controls according to age group. We found that of the youngest group of sampled patients (18-39?years), cases had the greatest adjusted OR for having previously been diagnosed with hyperthyroidism than controls (OR=1.98, 95% CI=1.04-3.79). Conclusions: This study demonstrated an association between UC and hyperthyroidism. ? 2017 John Wiley & Sons Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017535853&doi=10.1111%2fcen.13332&partnerID=40&md5=f179d7573c1fee82578e5d8ab42b1473 https://scholars.lib.ntu.edu.tw/handle/123456789/545823 |
ISSN: | 0300-0664 | DOI: | 10.1111/cen.13332 | SDG/關鍵字: | adult; Article; Asian; case control study; controlled study; disease association; female; geography; groups by age; human; hyperthyroidism; hypothyroidism; major clinical study; male; pathogenesis; population based case control study; priority journal; ulcerative colitis; urbanization; adolescent; aged; Asian continental ancestry group; complication; epidemiology; factual database; hyperthyroidism; middle aged; odds ratio; retrospective study; statistical model; Taiwan; ulcerative colitis; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Case-Control Studies; Colitis, Ulcerative; Databases, Factual; Female; Humans; Hyperthyroidism; Logistic Models; Male; Middle Aged; Odds Ratio; Retrospective Studies; Taiwan; Young Adult |
顯示於: | 醫學系 |
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