|Title:||Appendectomy increased the risk of ischemic heart disease||Authors:||Chen C.-H.
|Keywords:||Appendectomy; Appendix; Ischemic heart disease||Issue Date:||2015||Publisher:||Academic Press Inc.||Journal Volume:||199||Journal Issue:||2||Start page/Pages:||435-440||Source:||Journal of Surgical Research||Abstract:||
Background Although the appendix may not be considered vital, recent studies have noted adverse health consequences after appendectomy. This study aimed to use a population-based data set to explore whether appendectomy increases the risk for subsequent ischemic heart disease (IHD) in a 3-y follow-up period. Materials and methods This study used data from the Longitudinal Health Insurance Database 2000 in Taiwan. The study cohort included 5413 patients who underwent appendectomies. The comparison cohort was selected by randomly recruiting 16,239 enrollees matched with the study group in terms of sex, age, hypertension, hyperlipidemia, and diabetes. Each individual was tracked for 3 y to identify whether he and/or she developed IHD during the follow-up period. Cox proportional hazard regressions were performed for analysis. Results During a 3-y follow-up, 196 (3.62%) and 375 (2.31%) IHD incidents developed in the study and the comparison cohorts, respectively. For adults aged ?18 y, experiencing an appendectomy was independently associated with a 1.54-fold increased risk of IHD during the 3 y of follow-up (95% CI = 1.29-1.84). The association persisted in further analyses stratified by age. Conclusions There is an increased risk of subsequent IHD within 3 y after appendectomy, and this underscores the need for more serious clinical decision-making in removing the appendix. Regular monitoring for IHDs is also recommended for patients who have undergone an appendectomy. ? 2015 Elsevier Inc.
|ISSN:||0022-4804||DOI:||10.1016/j.jss.2015.06.049||SDG/Keyword:||adult; adverse effects; appendectomy; female; human; male; middle aged; Myocardial Ischemia; retrospective study; risk; Taiwan; young adult; Adult; Appendectomy; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Retrospective Studies; Risk; Taiwan; Young Adult
|Appears in Collections:||醫學系|
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