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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/545836
Title: An appendectomy increases the risk of rheumatoid arthritis: A five-year follow-up study
Authors: Tzeng Y.-M.
Kao L.-T.
Kao S.
Lin H.-C.
Tsai M.-C.
Lee, Cha-Ze 
Issue Date: 2015
Publisher: Public Library of Science
Journal Volume: 10
Journal Issue: 5
Source: PLoS ONE
Abstract: 
Many studies have reported a possible association of an appendectomy with rheumatoid arthritis (RA). However, findings of the relationship between an appendectomy and RA remain inconsistent. Furthermore, all such studies were conducted in Western societies, and relevant studies on the relationship between an appendectomy and RA in Asian countries are still lacking. In this study, we investigated the relationship between an appendectomy and the subsequent risk of RA using a population-based dataset. We retrieved data for this retrospective cohort study from the Taiwan "Longitudinal Health Insurance Database 2005". We included 4,294 subjects who underwent an appendectomy in the study cohort and 12,882 matched subjects in the comparison cohort. We individually tracked each subject for a 5-year period from their index date to identify those who developed RA. A stratified Cox proportional hazard regression was performed to calculate the hazard ratio (HR) and its corresponding 95% confidence interval (CI) for the subsequent development of RA during the 5-year follow-up period between subjects who underwent an appendectomy and comparison subjects. Of the sampled subjects, 93 (0.54%) received a diagnosis of RA during the 5-year follow-up period: 33 from the study cohort (0.77% of subjects who underwent an appendectomy) and 60 from the comparison cohort (0.47% of comparison subjects) (p<0.001). After censoring individuals who died during the follow-up period and adjusting for subjects' monthly income and geographic region, the HR of RA during the 5-year follow-up period was 1.61 (95% CI = 1.05?2.48) for subjects who underwent an appendectomy compared to comparison subjects. We found that among females, the adjusted HR of RA was 1.76 (95% CI = 1.04?2.96) for subjects who underwent an appendectomy compared to comparison subjects. However, there was no increased hazard of RA for males who underwent an appendectomy compared to comparison subjects. We concluded that female subjects who undergo an appendectomy have a higher risk of RA than comparison female subjects. ? 2015 Tzeng et al.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929323667&doi=10.1371%2fjournal.pone.0126816&partnerID=40&md5=233a689b8ff4943cfeefaf4a24ca7f69
https://scholars.lib.ntu.edu.tw/handle/123456789/545836
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0126816
SDG/Keyword: acute appendicitis; adult; aged; appendectomy; Article; cohort analysis; controlled study; female; follow up; geography; human; income; major clinical study; male; retrospective study; rheumatoid arthritis; risk assessment; Taiwan; adverse effects; appendectomy; Arthritis, Rheumatoid; case control study; middle aged; proportional hazards model; risk factor; sex ratio; Adult; Aged; Appendectomy; Arthritis, Rheumatoid; Case-Control Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Risk Factors; Sex Distribution
[SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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