C1QTNF6 as a novel diagnostic and prognostic biomarker for clear cell renal cell carcinoma.
Journal
DNA and Cell Biology
Journal Volume
39
Journal Issue
6
Pages
1000-1011
Date Issued
2020
Author(s)
Abstract
Clear cell renal cell carcinoma (ccRCC) is a highly aggressive disease and ?30% of the patients are diagnosed at the metastatic stage. Even with new targeted therapies, the average progression-free survival and overall survival (OS) rates are dismal. Thus, biomarkers for early detection and progression could improve disease outcome. The role of C1q/tumor necrosis factor (C1QTNF) family in cancer is an emerging field of research. However, the biological function of C1q/tumor necrosis factor-related protein 6 (C1QTNF6) and its prognostic value in cancer are rarely reported. This study aimed to evaluate C1QTNF6 as a potential diagnostic and prognostic biomarker for ccRCC. In this study, we enrolled 993 ccRCC samples (data from our cohort, The Cancer Genome Atlas, and Gene Expression Omnibus) with C1QTNF6 expression to explore its role and mechanism in ccRCC. The diagnostic power of C1QTNF6 was determined by receiver operating characteristic curve analysis and its prognostic value was evaluated by Kaplan-Meier analysis and Cox regression models, respectively. In addition, the gene set enrichment analysis was performed to unveil the molecular mechanism of C1QTNF6 in ccRCC. We demonstrated that C1QTNF6 was overexpressed in ccRCC, and elevated C1QTNF6 expression correlated with clinical progression. Besides, C1QTNF6 served as a new diagnostic biomarker for renal cell carcinoma. Moreover, C1QTNF6 is an independent risk factor for OS in ccRCC patients. Furthermore, C1QTNF6-related signaling pathways activated in ccRCC are mainly enriched in cell cycle, epithelial-mesenchymal transition, and angiogenesis signaling pathways. Taken together, our results provided insights in understanding the potential role of C1QTNF6 in promoting tumor growth, invasion, and metastasis, and its use as a novel cancer diagnostic and prognostic biomarker for ccRCC. ? Copyright 2020, Mary Ann Liebert, Inc.
Subjects
bioinformatics; biomarker; C1QTNF6; clear cell renal cell carcinoma; diagnosis and prognosis
SDGs
Other Subjects
adult; angiogenesis; Article; C1QTNF6 gene; cancer growth; cancer prognosis; cohort analysis; controlled study; epithelial mesenchymal transition; female; gene expression; genetic association; human; human tissue; major clinical study; male; microarray analysis; overall survival; priority journal; progression free survival; receiver operating characteristic; renal cell carcinoma; signal transduction; cancer staging; gene expression regulation; genetics; kidney tumor; metabolism; pathology; prognosis; renal cell carcinoma; risk factor; C1qTNF6 protein, human; collagen; tumor marker; Biomarkers, Tumor; Carcinoma, Renal Cell; Collagen; Female; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Male; Neoplasm Staging; Prognosis; Risk Factors; Signal Transduction
Publisher
New York:Mary Ann Liebert Inc.
Type
journal article