|Title:||Fast-Target Analysis and Hourly Variation of 60 Pharmaceuticals in Wastewater Using UPLC-High Resolution Mass Spectrometry||Authors:||Hong, Y.
|Issue Date:||2020||Journal Volume:||69||Journal Issue:||4||Source:||Archives of Environmental Contamination and Toxicology||Abstract:||
A fast and sensitive monitoring method for trace pharmaceuticals in the environment is vital because many of these compounds are ubiquitous, persistent, and biologically active with recognized endocrine-disruption and pharmacological functions. A rapid and reliable ultra high-performance liquid chromatography combined with tandem mass spectrometry was developed in the present study to simultaneously identify, confirm, and quantify 60 target pharmaceuticals in wastewater samples. The method uses a sub-2 µm particle column for separating target compounds, which were subsequently quantified with the mass spectrometer. Using this high-throughput analysis method, a single injection could provide results within 5 min for the pharmaceuticals. All of the target compounds were analyzed by the multiple-reaction monitoring with 15-ms fast polarity switching. Both intraday and interday precision analyses indicate excellent coefficient of variability. To evaluate the performance of the method, a standard solution (100 and 1000 ng L−1) was spiked into complex wastewater samples. The tailing factor and peak width were also monitored and adjusted for optimizing peaks from the ultra high-performance liquid chromatograph. Of the target pharmaceuticals in wastewater of a sewage-treatment plant analyzed on an hourly basis, only 17 compounds were detected, and others were lower than the method detection limits. Acetaminophen, cimetidine, and iopromide were all detected at >1 μg L−1, and their concentration profiles were similar to that of a nonsteroidal anti-inflammatory drug detected in wastewater. Other noticeable pharmaceuticals were sulfamethoxazole and trimethoprim. Sources of pharmaceuticals in wastewater are briefly discussed. © 2015 Springer Science+Business Media New York
|DOI:||10.1007/s00244-015-0214-z||SDG/Keyword:||drug; endocrine disruptor; waste water; water pollutant; analysis; chemistry; environmental monitoring; high performance liquid chromatography; procedures; solid phase extraction; tandem mass spectrometry; waste water; water pollutant; Chromatography, High Pressure Liquid; Endocrine Disruptors; Environmental Monitoring; Pharmaceutical Preparations; Solid Phase Extraction; Tandem Mass Spectrometry; Waste Water; Water Pollutants, Chemical
|Appears in Collections:||環境工程學研究所|
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