Blockade of PD-L1 enhances cancer immunotherapy by regulating dendritic cell maturation and macrophage polarization
Journal
Cancers
Journal Volume
11
Journal Issue
9
Pages
1400
Date Issued
2019
Author(s)
Sun N.-Y.
Wu W.-Y.
Lin H.-W.
Chang C.-F.
Abstract
T lymphocytes) and anti-tumor effects than protein vaccine alone. Anti-PD-L1 antibody enhanced the maturation of dendritic cells and the proportion of M1-like macrophages in tumor-draining lymph nodes and tumors in tumor-bearing mice treated with combinatorial therapy. PD-L1 blockade overturned the immunosuppressive status of the tumor microenvironment and then enhanced the E7 tumor-specific antigen-specific immunity and anti-tumor effects generated by an E7-specific protein vaccine through modulation of APCs in an E7-expressing small tumor model. Tumor-specific antigen (like HPV E7 antigen)-specific immunotherapy combined with APC-targeting modality by PD-L1 blockade has a high translational potential in E7-specific cancer therapy.
SDGs
Publisher
MDPI AG
Type
journal article