Intraperitoneal and intracardiac transfusion of recurrent fetal erythroblastosis due to anti-M alloimmunization with unfavorable outcome
Journal
Taiwanese Journal of Obstetrics and Gynecology
Journal Volume
51
Journal Issue
2
Pages
253-255
Date Issued
2012
Author(s)
Abstract
Objective: To present intensive intrauterine treatment of recurrent early onset fetal erythroblastosis due to anti-M alloimmunization. Case Report: A 33-year-old woman, gravid 3, para 1, had anti-M IgG antibody, which caused alloimmunization of her previous pregnancies. This time she visited our hospital for intensive intervention. No evidence of fetal hydrops was found during ultrasound examination at 12 weeks of gestation. Plasmapheresis was given from 17 weeks of gestation but fetal erythroblastosis still developed 1 week later. Two intraperitoneal transfusions and one intracardiac transfusion were given within three days but fetal erythroblastosis still progressed to fetal bradycardia and occasional asystole. Epinephrine resuscitation could only temporarily improve the fetal heart rate and fetal death was inevitable. Conclusion: Serial measurements of fetal middle cerebral artery peak systolic velocities, advanced plasmapheresis, intrauterine blood transfusion, and, if needed, intravenous immunoglobulin supplement, may be the appropriate treatment for early onset fetal erythroblastosis resulting from alloimmunization. ? 2012 .
SDGs
Other Subjects
adrenalin; hemoglobin F; immunoglobulin; immunoglobulin M antibody; adult; alloimmunization; anemia; article; bradycardia; case report; cordocentesis; female; fetus death; gestational age; heart rate; hematocrit; hemoglobin blood level; human; intrauterine blood transfusion; newborn hemolytic disease; outcome assessment; pericardial effusion; plasmapheresis; recurrent disease; skin edema; Adult; Blood Transfusion, Intrauterine; Erythroblastosis, Fetal; Female; Fetal Death; Humans; Hydrops Fetalis; Immunoglobulin G; Immunoglobulin M; Peritoneal Cavity; Plasmapheresis; Pregnancy; Recurrence; Ultrasonography, Prenatal
Type
journal article