|Title:||The effects of continuous epidural analgesia on Doppler velocimetry of uterine arteries during different periods of labour analgesia||Authors:||LI-KUEI CHEN
|Issue Date:||2006||Publisher:||Oxford University Press||Journal Volume:||96||Journal Issue:||2||Start page/Pages:||226-230||Source:||British Journal of Anaesthesia||Abstract:||
Background. The transient effects of epidural bupivacaine 0.25-0.5% on the Doppler velocimetry of umbilical and uterine arteries had been reported, but the effects of continuous lower dose epidural bupivacaine (0.05-0.1%) infusion for labour analgesia have never been reported. In this study, we evaluated the effects of continuous epidural bupivacaine 0.075% on the Doppler velocimetry of uterine arteries. Methods. Twenty pregnant women for labour analgesia received continuous epidural bupivacaine 0.075% infusion. We used a 4-MHz continuous-wave Doppler probe (Multigon 500A) with a 200 Hz thump filter to detect uterine blood flow velocity. We recorded the velocimetry data for uterine relaxation and contraction during five time periods: Pre-epidural insertion, 1, 2, and 4 h post-epidural infusion, and after delivery of fetus. Results. Our data showed that the velocimetric indices of uterine vascular resistance were significantly increased 1, 2, and 4 h after epidural infusion when compared with the pre-epidural level; these returned to the baseline after delivery. Conclusion. Continuous epidural analgesia with bupivacaine 0.075% increases the resistance of uterine artery and therefore possibly reduces the uterine blood flow. ? The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved.
|ISSN:||0007-0912||DOI:||10.1093/bja/aei311||SDG/Keyword:||bupivacaine; lidocaine; article; bradycardia; childbirth; clinical article; continuous epidural anesthesia; controlled study; Doppler flowmetry; drug dose regimen; drug efficacy; drug infusion; female; fetus; fetus disease; filter; human; hypotension; hypovolemia; medical record; obstetric anesthesia; postoperative period; pregnant woman; preoperative period; priority journal; uterine artery; uterus blood flow; uterus contraction; uterus relaxation; vascular resistance
|Appears in Collections:||醫學系|
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