Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Association of polymorphisms of interleukin-1β gene and Helicobacter pylori infection with the risk of gastric ulcer
 
  • Details

Association of polymorphisms of interleukin-1β gene and Helicobacter pylori infection with the risk of gastric ulcer

Journal
Hepato-Gastroenterology
Journal Volume
49
Journal Issue
47
Pages
1474-1476
Date Issued
2002
Author(s)
YU-TING CHANG  
MING-SHIANG WU  
CHIA-TUNG SHUN  
MING-TSAN LIN  
MING-CHU CHANG  
Lin J.-T.
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036375148&partnerID=40&md5=4246cbc6ade287a173d7ff1b200a8e13
https://scholars.lib.ntu.edu.tw/handle/123456789/548412
Abstract
Background/Aims: Interleukin-1β (IL-1β) plays an important role in gastric inflammation and physiology. Functional polymorphisms of IL-1β gene have been related to different risks of gastric cancer and duodenal ulcer but their role in gastric ulcer remains unknown. In this study, we investigate a plausible association between gastric ulcer and the polymorphisms in the IL-1β and IL-1 receptor antagonist (IL-1RN) genes. The relationships among the cytokine genotyping, other environmental risks such as Helicobacter pylori infection and smoking, and clinical characteristics of gastric ulcer were also determined. Methodology: Peripheral blood DNAs from 120 unrelated Taiwan Chinese patients with gastric ulcer and 238 ethnically matched healthy controls were genotyped for the promoter (position -31 and -511) and Taq I polymorphism (position +3954) in the IL-1β gene and the variable number of tandem repeats polymorphisms in intron 2 of the IL-1RN gene. The status of Helicobacter pylori infection was determined by serology. Results: The seropositive rate of Helicobacter pylori (95/120 vs. 134/238, OR: 2.95, 95%CI 1.77-4.91), habitual smoking (67/120 vs. 82/238, OR: 2.40, 95%CI 1.54-3.77) and blood group O (63/120 vs. 98/238, OR: 1.55, 95%CI 1.0-2.41) were significantly higher in patients with gastric ulcer than controls. The distributions of allele frequencies of IL-1β (-31 C/T or -511 C/T or +3954) and IL-1RN were similar between patients with gastric ulcer and controls. No significant differences were observed, including those analyzed after stratification of the infected population and by the ulcer subgroup. Conclusions: Our data suggested that Helicobacter pylori infection, cigarette smoking, and blood group O are risk factors of gastric ulcer and IL-1β or IL-1RN polymorphisms do not influence susceptibility to gastric ulcer in a Taiwanese population.
SDGs

[SDGs]SDG3

Other Subjects
cytokine; DNA; interleukin 1 receptor blocking agent; interleukin 1beta; adult; article; Chinese; cigarette smoking; clinical feature; controlled study; DNA polymorphism; environmental factor; ethnic group; female; genotype; habit; Helicobacter infection; Helicobacter pylori; human; intron; major clinical study; male; priority journal; promoter region; risk assessment; serology; stomach ulcer; Taiwan; variable number of tandem repeat; Aged; Female; Genetic Predisposition to Disease; Helicobacter Infections; Helicobacter pylori; Humans; Interleukin-1; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; Stomach Ulcer
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science