https://scholars.lib.ntu.edu.tw/handle/123456789/548483
標題: | A long-term follow-up study of 176 cases with adult-type ovarian granulosa cell tumors | 作者: | Sun H.-D. Lin H. Jao M.-S. Wang K.-L. Liou W.-S. Hung Y.-C. YING-CHENG CHIANG Lu C.-H. Lai H.C. Yu M.-H. |
關鍵字: | Characteristics of recurrence; Granulosa cell tumors; Outcomes | 公開日期: | 2012 | 卷: | 124 | 期: | 2 | 起(迄)頁: | 244-249 | 來源出版物: | Gynecologic Oncology | 摘要: | Objective: Because of rarity, indolent clinical course, and of most importance, small sample size studies of previous ovarian granulosa cell tumors (GCTs), this study was conducted to report the clinical characteristics and long-term outcomes of 176 pathologically confirmed GCTs. Methods: Between 1984 and 2010, we retrospectively evaluated 176 patients from multiple medical centers in Taiwan. Results: The mean age at the diagnosis was 46 years and nearly half of the patients (45.7%) were in their fourth or fifth decades of life. The most common symptoms included abdominal pain (28.5%), followed by irregular menstruation (16.7%). The mean tumor size was 10.4 cm. The stage distribution at diagnosis was stage I in 77.8% of patients, stage II in 5.1%, stages III-V in 6.1%, and unknown in 11% of patients. The median follow-up period was 60.7 months. The recurrence rate was 21%. The overall 5- and 10-year survival rates were 96.5% and 94.1%, respectively. In univariate analysis, initial stage, presence of residual tumor after initial surgery, need for adjuvant chemotherapy, and tumor size were associated with disease recurrence. In the multivariate analysis, only the presence of residual tumor after initial surgery and tumor size were significantly associated with recurrence. Conclusions: The outcomes of patients with GCTs were good, with nearly to 95% of patients surviving 5 and 10 years. The prognosis was related to initial stage, presence of residual tumor after initial surgery, and tumor size (> 13.5 cm). Different surgical methods and/or adjuvant therapy appear not to affect the outcome. ? 2011 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856009067&doi=10.1016%2fj.ygyno.2011.10.015&partnerID=40&md5=8097829417b4db9d40b8e11a855c6438 https://scholars.lib.ntu.edu.tw/handle/123456789/548483 |
ISSN: | 0090-8258 | DOI: | 10.1016/j.ygyno.2011.10.015 | SDG/關鍵字: | abdominal pain; adult; aged; article; cancer adjuvant therapy; cancer prognosis; cancer recurrence; cancer staging; disease association; female; follow up; granulosa cell tumor; human; major clinical study; menstrual irregularity; outcome assessment; priority journal; retrospective study; survival rate; Taiwan; tumor volume; Adult; Aged; Disease-Free Survival; Female; Follow-Up Studies; Granulosa Cell Tumor; Humans; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Ovarian Neoplasms; Prognosis; Retrospective Studies; Treatment Outcome; Young Adult |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。