Early neuropsychiatric involvement in antiphospholipid syndrome
Journal
General Hospital Psychiatry
Journal Volume
34
Journal Issue
5
Pages
579.e1-579.e3
Date Issued
2012
Author(s)
Abstract
Objective: Neuropsychiatric symptoms may be the main manifestations and very early symptoms of developing autoimmune diseases. Early detection and treatment could reverse psychotic symptoms and restore cognitive function. Case Report: A 24-year-old woman presented with acute psychotic symptoms. Routine physical examinations revealed only mild fever. Due to positive antiphospholipid antibodies, low protein S with elevated d-dimer and brain hypoperfusion, early-phase antiphospholipid syndrome (APS) was suspected. Early immunomodulation treatment led to complete remission of the psychotic symptoms, preservation of cognitive function and prevention of APS progression. Conclusion: Since early detection and treatment can reverse the progression of autoimmune diseases with central nervous system involvement, these should be highlighted when managing high-risk patients. ? 2012 Elsevier Inc.
SDGs
Other Subjects
acetylsalicylic acid; aciclovir; cardiolipin antibody; ceftriaxone; D dimer; hydroxychloroquine; immunoglobulin G antibody; methylprednisolone; olanzapine; phospholipid antibody; prednisolone; protein S; acute psychosis; adult; antiphospholipid syndrome; article; brain hypoperfusion; brain perfusion; case report; clinical feature; cognition; differential diagnosis; drug pulse therapy; early diagnosis; early intervention; female; fever; follow up; human; immunomodulation; infection; low drug dose; neurologic examination; persecutory delusion; physical examination; remission; schizophrenia; serology; single photon emission computer tomography; symptom; Wechsler Intelligence Scale
Type
journal article