https://scholars.lib.ntu.edu.tw/handle/123456789/548583
標題: | Protective effects of antioxidant egg-chalaza hydrolysates against chronic alcohol consumption-induced liver steatosis in mice | 作者: | Yang, Kuo-Tai Lin, Yi-Ling Lin, Yu-Xuan SHENG-YAO WANG Wu, Yi-Hsieng S CHUNG-HSI CHOU Fu, Shih-Guei YI-CHEN CHEN |
公開日期: | 2019 | 卷: | 99 | 期: | 5 | 起(迄)頁: | 2300-2310 | 來源出版物: | Journal of the Science of Food and Agriculture | 摘要: | BACKGROUND: Reactive oxygen species (ROS) overproduction is highly related to some human chronic diseases. There are approximately 400 metric tons of chalazae produced yearly after the processing of the liquid-egg production, which are disposed of as waste. The objectives of this study were to look for the optimal production condition of antioxidant crude chalaza hydrolysates and evaluate the in vivo antioxidant capacity via a chronic alcohol consumption mouse model. RESULTS: Antioxidant crude chalaza hydrolysates (CCH-As) could be produced by protease A at 1:100 ratio (w/w) and 0.5 h hydrolytic period. After our analyses, CCH-As were rich in leucine, arginine, phenylalanine, valine, lysine and antioxidant dipeptides (anserine and carnosine), and the major molecular masses were lower than 15 kDa. Regarding protective effects of CCH-As against oxidative damage in alcoholic-liquid-diet-fed mice, alcohol-fed mice had lower (P < 0.05) liver antioxidant capacities, and higher (P < 0.05) liver lipid contents, serum lipid/liver damage indices and IL-1β/IL-6 values. CCH-A supplementation reversed (P < 0.05) liver antioxidant capacities and reduced (P < 0.05) serum/liver lipids in alcohol-fed mice, which may result from increased (P < 0.05) fecal lipid output, upregulated (P < 0.05) fatty acid β-oxidation and downregulated (P < 0.05) lipogenesis in the liver. CONCLUSION: Taken together, this CCH-A should benefit the liquid-egg industry, while also offering consumers a choice of healthy ingredients from animal sources. ? 2018 Society of Chemical Industry. ? 2018 Society of Chemical Industry |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85057453081&partnerID=40&md5=dc0449e9d7281255bcb90c9c8362e283 https://scholars.lib.ntu.edu.tw/handle/123456789/548583 |
DOI: | 10.1002/jsfa.9426 | SDG/關鍵字: | antioxidant; interleukin 6; protein hydrolysate; reactive oxygen metabolite; analysis; animal; C57BL mouse; chemistry; chicken; drinking behavior; drug effect; egg yolk; fatty liver; human; liver; male; metabolism; mouse; waste; Alcohol Drinking; Animals; Antioxidants; Chickens; Egg Yolk; Fatty Liver; Humans; Interleukin-6; Liver; Male; Mice; Mice, Inbred C57BL; Protein Hydrolysates; Reactive Oxygen Species; Waste Products |
顯示於: | 動物科學技術學系 |
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