Successful treatment of gestational trophoblastic neoplasia in the uterine cornus with laparoscopic cornuostomy and postoperative methotrexate injection
Journal
Taiwanese Journal of Obstetrics and Gynecology
Journal Volume
56
Journal Issue
2
Pages
261-263
Date Issued
2017
Author(s)
Abstract
Objective Management of cornual gestational trophoblastic neoplasia (GTN) has never been reported. Here, we describe the first case of cornual GTN. Case Report A 32-year-old woman was diagnosed with left cornual GTN after evacuation of a complete mole. Laparoscopic cornuostomy was performed with intramural vasopression injection and barbed sutures. Histopathology revealed hydropic chorionic villi. Complete hydatidiform mole was diagnosed, and treated with adjuvant methotrexate, to address the poor decline of β-human chorionic gonadotropin levels during follow-up. The β- human chorionic gonadotropin levels declined to < 1?mIU/mL 9 months after cornuostomy. She successfully conceived 16 months after cornuostomy, and underwent cesarean section at 37 gestational weeks due to concomitant severe preeclampsia. Conclusion Cornual GTN can be successfully managed with laparoscopic cornuostomy and adjuvant methotrexate. ? 2017
SDGs
Other Subjects
chorionic gonadotropin; methotrexate; vasopressin; antineoplastic antimetabolite; methotrexate; adjuvant therapy; Article; barbed suture; case report; cesarean section; chorion villus; curettage; cytotrophoblast; echography; female; follow up; gestational age; gonadotropin blood level; histopathology; human; human tissue; hydatidiform mole; laparoscopic cornuostomy; laparoscopic surgery; lower abdominal pain; nuclear magnetic resonance imaging; postoperative care; preeclampsia; pregnancy; surgical wound; syncytiotrophoblast; trophoblast; trophoblastic tumor; adjuvant chemotherapy; adult; hydatidiform mole; laparoscopy; surgery; uterus; uterus cancer; Adult; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Female; Humans; Hydatidiform Mole; Laparoscopy; Methotrexate; Pregnancy; Uterine Neoplasms; Uterus
Publisher
Elsevier Ltd
Type
journal article