https://scholars.lib.ntu.edu.tw/handle/123456789/550239
標題: | Hepatitis B post-partum e antigen clearance in hepatitis B carrier mothers: Correlation with viral characteristics | 作者: | HO-HSIUNG LIN Wu W.-Y. JIA-HORNG KAO DING-SHINN CHEN |
公開日期: | 2006 | 出版社: | Blackwell Publishing | 卷: | 21 | 期: | 3 | 起(迄)頁: | 605-609 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background: The purpose of the present paper was to correlate hepatitis B virus (HBV) genotype, e antigen titer, HBV-DNA level and precore/basal core promoter mutations with post-partum e antigen clearance in hepatitis B e antigen (HBeAg)-positive carrier mothers. Methods: A total of 40 consecutive HBeAg-positive carrier mothers were studied from January 2002 to January 2003. The blood samples were taken at delivery, 3-4 months and at 1 year after delivery, and the follow-up period was until 1 year after delivery. All sera were assayed for HBeAg, HBV-DNA level, HBV genotype and precore/basal core promoter mutations. The correlation between HBV characteristics and post-partum e antigen clearance was analyzed by Mann-Whitney, Pearson χ2 and multiple logistic regression tests. Results: The mean age of the 40 HBeAg-positive carrier mothers was 29.9 ± 5.3 years with a mean parity of 1.4 ± 0.7. Five of them (group I) had post-partum e antigen clearance, which persisted thereafter, whereas the remaining 35 carrier mothers (group II) had persistent positivity of HBeAg during the follow-up period. The prepartum comparisons of HBV characteristics between groups I and II were comparable in terms of demographics and distributions of HBV genotype and precore/basal core promoter mutations. In contrast, group I carrier mothers had lower HBeAg titer and HBV-DNA level than group II carrier mothers (1:80 vs 1:4000, P = 0.02, and 3.75 × 105 vs 3 × 108 copies/mL, P = 0.028, respectively). Conclusions: Post-partum e antigen clearance in HBeAg-positive carrier mothers is closely associated with prepartum low HBeAg titer or HBV-DNA level. ? Blackwell Publishing Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33645029813&doi=10.1111%2fj.1440-1746.2006.04198.x&partnerID=40&md5=d389cd3e847f89aab44c1eff2cb9344e https://scholars.lib.ntu.edu.tw/handle/123456789/550239 |
ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.2006.04198.x | SDG/關鍵字: | hepatitis E antigen; virus DNA; adult; article; blood sampling; clinical article; controlled study; correlation coefficient; delivery; demography; female; follow up; gene mutation; genotype; hepatitis B; human; multivariate logistic regression analysis; mutational analysis; parity; priority journal; promoter region; puerperium; rank sum test; virus carrier; virus characterization |
顯示於: | 醫學系 |
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