https://scholars.lib.ntu.edu.tw/handle/123456789/550249
標題: | Secular trend of age-specific prevalence of hepatitis B surface and e antigenemia in pregnant women in Taiwan | 作者: | HO-HSIUNG LIN JIA-HORNG KAO TING-CHEN CHANG HONG-YUAN HSU DING-SHINN CHEN |
公開日期: | 2003 | 卷: | 69 | 期: | 4 | 起(迄)頁: | 466-470 | 來源出版物: | Journal of Medical Virology | 摘要: | To elucidate the impact of aging of hepatitis B carrier women on their viral replicative markers in a hepatitis B endemic area, all the parturients admitted to the Hospital were studied from 1985 to 2000. Serum hepatitis B surface (HBsAg) and hepatitis B e antigen (HBeAg) were tested by radioimmunoassay. Mann-Whitney U and Student's t-tests were used for statistical analysis. The results showed the yearly prevalence rate of HBsAg in pregnant women seemed stable with a mean of 12.0 ± 1.1% during the period. The yearly positive rate of HBeAg among HBsAg-positive pregnant women varied between 30.4% and 42.6% from 1985 to 1992 and declined from 29.6% in 1993 to 18.1% in 2000. The mean ratio of HBeAg/HBsAg in carrier parturients was 24.7% [intraquantile range (IQR) 20.5-28.4] from 1993 to 2000, which was significantly lower than that of 32.4% (IQR 31.0-39.0) from 1985 to 1992 (P < 0.0001). The mean age of HBeAg-positive primiparas from 1993 to 2000 was 29.1 ± 3.9 years and significantly higher than that of 28.0 ± 3.7 years from 1985 to 1993 (P < 0.001), as well as in secundiparas 31.2 ± 3.8 years vs. 30.1 ± 3.4 years (P < 0.001) and in total parturients 30.3 ± 4.2 years vs. 29.3 ± 3.8 years (P < 0.001). Thus, no significant decrease of HBsAg carriage was observed in the past 16 years, whereas a decreased ratio of HBeAg/HBsAg was noted in carrier parturients in the past 8 years and the elderly HBeAg-positive parturients from 1993 to 2000 may be the cause. ? 2003 Wiley-Liss, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0345073709&doi=10.1002%2fjmv.10332&partnerID=40&md5=17f8e54cd326bfefe8d384f33b25b7c7 https://scholars.lib.ntu.edu.tw/handle/123456789/550249 |
ISSN: | 0146-6615 | DOI: | 10.1002/jmv.10332 | SDG/關鍵字: | hepatitis B antibody; hepatitis B surface antigen; hepatitis B vaccine; hepatitis B(e) antigen; adult; age; article; controlled study; endemic disease; female; hepatitis B; Hepatitis B virus; human; immunization; major clinical study; parity; perinatal infection; pregnancy; radioimmunoassay; rank sum test; seroprevalence; Student t test; Taiwan; virus carrier; virus replication; Adolescent; Adult; Age Distribution; Age Factors; Carrier State; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Pregnancy; Pregnancy Complications, Infectious; Prevalence; Taiwan; Hepatitis B virus |
顯示於: | 醫學系 |
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