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  4. Antiviral therapy against chronic hepatitis C is associated with a reduced risk of oral cancer
 
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Antiviral therapy against chronic hepatitis C is associated with a reduced risk of oral cancer

Journal
International Journal of Cancer
Journal Volume
147
Journal Issue
3
Pages
901-908
Date Issued
2020
Author(s)
TUNG-HUNG SU  
TAI-CHUNG TSENG  
CHUN-JEN LIU  
Chou S.-W
CHEN-HUA LIU  
HUNG-CHIH YANG  
PEI-JER CHEN  
DING-SHINN CHEN  
CHI-LING CHEN  
JIA-HORNG KAO  
DOI
10.1002/ijc.32840
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078586776&doi=10.1002%2fijc.32840&partnerID=40&md5=4d79980008e7f18c74bd81172e5f9f33
https://scholars.lib.ntu.edu.tw/handle/123456789/551048
Abstract
To identify the risk factors of oral cancer, we investigated the association between chronic hepatitis C (CHC) and oral cancer, and the development of oral cancer after anti-hepatitis C virus (HCV) therapy. We conducted a nationwide, population-based cohort study from 2004 to 2012 from the Taiwan National Health Insurance Research Database. CHC patients without anti-HCV therapy were matched with those non-HCV patients by age, sex and comorbidities. Moreover, CHC patients who underwent pegylated interferon and ribavirin (PegIFN/RBV) anti-HCV therapy were matched with CHC patients without anti-HCV therapy. A total of 100,058 patients were included in the HCV cohort and non-HCV cohorts, respectively. Their mean age was 59 years and 50% of these were male. CHC infection significantly increased the cumulative incidence of lichen planus and oral cancer. After adjustment for confounders and competing mortality, CHC infection significantly increased the risk of oral cancer (hazard ratio [HR]: 1.677, 95% confidence interval [CI]: 1.392–2.020, p < 0.001). Another 23,735 CHC patients without anti-HCV therapy were matched with 23,735 CHC patients in the treatment cohort. After adjustment for confounders and competing for mortality, the risk of oral cancer was significantly reduced in CHC patients receiving anti-HCV therapy (HR: 0.652, 95% CI: 0.479–0.887, p = 0.007). To minimize the inclusion of pre-existing unidentified oral cancer, we excluded oral cancer developed within the first year of CHC or anti-HCV therapy and found these associations remained statistically significant. In conclusion, CHC significantly increases the risk of oral cancer. Moreover, PegIFN/RBV antiviral therapy significantly reduces the risk of HCV-related oral cancer. ? 2019 UICC
SDGs

[SDGs]SDG3

Other Subjects
peginterferon; ribavirin; antivirus agent; interferon; ribavirin; adult; antiviral therapy; Article; cancer prevention; cancer risk; chronic hepatitis C; cohort analysis; confidence interval; confounding variable; disease association; female; human; incidence; lichen planus; major clinical study; male; middle aged; mortality; mouth cancer; population research; priority journal; risk assessment; risk factor; risk reduction; Taiwan; trend study; aged; case control study; chronic hepatitis C; combination drug therapy; mouth tumor; Adult; Aged; Antiviral Agents; Case-Control Studies; Confounding Factors, Epidemiologic; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferons; Male; Middle Aged; Mouth Neoplasms; Ribavirin; Taiwan
Publisher
Wiley-Liss Inc.
Type
journal article

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