Value of interleukin-28B genetic polymorphism on retreatment outcomes of chronic hepatitis C genotype 1 relapsers by peginterferon alfa plus ribavirin
Journal
Journal of Gastroenterology and Hepatology (Australia)
Journal Volume
29
Journal Issue
1
Pages
102-109
Date Issued
2014
Author(s)
Chen M.-Y.
Chen T.-C.
Abstract
Background and Aim: Chronic hepatitis C (CHC) infection is a leading cause of cirrhosis and hepatocellular carcinoma worldwide. Pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy remains the standard of care for CHC genotype 1 in many Asian countries, and single nucleotide polymorphism or genotype of the interleukin-28B (IL28B) gene is associated with the development of sustained virologic response (SVR). The predictive value of IL28B genotype for retreatment outcomes of patients with CHC was only partly clarified and deserves further investigation. Methods: A total of 75 CHC genotype 1 Taiwanese patients who relapsed after 24-week PEG-IFN/RBV combination therapy and received retreatment with a 48-week PEG-IFN/RBV therapy were consecutively enrolled since November 2009. The associations among IL28B rs8099917 genotype, virologic kinetics, and treatment outcomes were evaluated. Results: Rapid virologic response (RVR) at week 4, end-of-treatment virologic response (EOT-VR) and SVR was 37%, 73%, and 52%, respectively. Relapse rate was 29%. None of patients had rs8099917 GG genotype. Patients with TT genotype (n=54, 72%) had higher rates of RVR (50% vs 5%, P=0.0002), end-of-treatment virologic response (85% vs 43%, P=0.0001), and SVR (67% vs 14%, P=0.0001) than those with GT genotype (n=21, 28%). Combination of IL28BTT genotype and achieving RVR had 85% positive and 90% negative predictive values of SVR. Conclusions: About half of the Taiwanese CHC relapsers to a previous 24-week combination therapy achieve SVR after retreatment for 48 weeks. IL28B genotype influences on-treatment viral kinetics and SVR rate in these retreated patients. Baseline IL28B genotype and RVR can serve as early predictors for treatment success. ? 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
SDGs
Other Subjects
interleukin 28B; peginterferon alpha2a; peginterferon alpha2b; peginterferon alpha2b plus ribavirin; ribavirin; adult; article; combination chemotherapy; controlled study; female; genotype; hepatitis C; human; major clinical study; male; microbial kinetics; middle aged; predictive value; priority journal; recurrence risk; retreatment; single blind procedure; single nucleotide polymorphism; Taiwan; treatment outcome; treatment response; chronic hepatitis C; genotype; IL28B; pegylated interferon; retreatment; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Genotype; Hepatitis C, Chronic; Humans; Interferon-alpha; Interleukins; Male; Middle Aged; Multivariate Analysis; Polyethylene Glycols; Polymorphism, Genetic; Prospective Studies; Recombinant Proteins; Recurrence; Ribavirin; Taiwan; Time Factors; Treatment Outcome
Type
journal article