https://scholars.lib.ntu.edu.tw/handle/123456789/551126
標題: | Hepatitis B surface antigen level complements viral load in predicting viral reactivation in spontaneous HBeAg seroconverters | 作者: | TAI-CHUNG TSENG CHUN-JEN LIU Yang W.-T CHI-LING CHEN HUNG-CHIH YANG TUNG-HUNG SU Wang C.-C Kuo S.F.-T CHEN-HUA LIU PEI-JER CHEN DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2014 | 出版社: | Blackwell Publishing | 卷: | 29 | 期: | 6 | 起(迄)頁: | 1242-1249 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background and Aims: The level of hepatitis B surface antigen (HBsAg) has been shown to complement hepatitis B virus (HBV)-DNA level in predicting disease progression in hepatitis B e antigen (HBeAg)-negative patients, especially those with low viral loads. Whether this finding could be seen in spontaneous HBeAg seroconverters remains unclear. Methods: A retrospective cohort of 390 Taiwanese spontaneous HBeAg seroconverters with a mean follow-up period of 7.4 years was enrolled. The relationships between HBV-DNA/HBsAg levels and HBeAg-negative hepatitis/active viral replication (HBV-DNA level ?2000IU/mL) were investigated. Results: In the overall cohort, serum HBV-DNA level served as a better predictor for HBeAg-negative hepatitis compared with HBsAg level. However, in those with HBV-DNA level <2000IU/mL, a higher HBsAg level was associated with a higher risk of HBeAg-negative hepatitis (P=0.015). Multivariate analysis showed the hazard ratio of HBsAg level ?1000IU/mL versus <1000IU/mL was 4.1 (95% confidence interval: 1.3-13.6). When using the end-point of active viral replication, HBsAg ?1000IU/mL remained as an independent risk factor, with a hazard ratio of 2.5 (95% confidence interval: 1.1-5.9). Conclusions: In spontaneous HBeAg seroconverters with HBV-DNA level <2000IU/mL, HBsAg level ?1000IU/mL is associated with increased risks of HBeAg-negative hepatitis and active viral replication. Combining HBV-DNA <2000IU/mL and HBsAg level <1000IU/mL may be used to define minimal viral activity. ? 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84900549965&doi=10.1111%2fjgh.12502&partnerID=40&md5=8f254e254497bddd682d3950048774cb https://scholars.lib.ntu.edu.tw/handle/123456789/551126 |
ISSN: | 0815-9319 | DOI: | 10.1111/jgh.12502 | SDG/關鍵字: | hepatitis B surface antigen; hepatitis B(e) antigen; virus DNA; biological marker; hepatitis B surface antigen; hepatitis B(e) antigen; adult; article; controlled study; female; follow up; hepatitis B; Hepatitis B virus; human; infection risk; major clinical study; male; nonhuman; priority journal; retrospective study; risk factor; seroconversion; Taiwan; virus load; virus reactivation; virus replication; blood; cohort analysis; disease course; genetics; hepatitis B; Hepatitis B virus; immunology; physiology; serology; time; virology; virus activation; virus load; virus replication; Adult; Biological Markers; Cohort Studies; Disease Progression; DNA, Viral; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Retrospective Studies; Serologic Tests; Time Factors; Viral Load; Virus Activation; Virus Replication |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。