https://scholars.lib.ntu.edu.tw/handle/123456789/551128
標題: | Risk stratification of hepatocellular carcinoma in hepatitis B virus e antigen-negative carriers by combining viral biomarkers | 作者: | TAI-CHUNG TSENG CHUN-JEN LIU CHI-LING CHEN HUNG-CHIH YANG TUNG-HUNG SU Wang C.-C Yang W.-T Kuo S.F.-T CHEN-HUA LIU PEI-JER CHEN DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2013 | 出版社: | Oxford University Press | 卷: | 208 | 期: | 4 | 起(迄)頁: | 584-593 | 來源出版物: | Journal of Infectious Diseases | 摘要: | Background. The serum hepatitis B virus (HBV) surface antigen (HBsAg) level can predict hepatocellular carcinoma (HCC) development in hepatitis B e antigen (HBeAg)-negative patients with an HBV DNA level of <2000 IU/mL. However, little is known regarding how well the combination of both viral biomarkers stratifies HCC risk. Methods. A total of 2165 Taiwanese HBeAg-negative noncirrhotic patients were followed for 14.9 years. The predictive power of the HBsAg level for HCC was analyzed for different viral load ranges. Results. In patients with HBV DNA levels of 2000-19 999 IU/mL (intermediate viral load), a positive correlation between HBsAg level and HCC development was identified after adjustment for other risk factors (P =. 002). In contrast, no association was found between HBsAg level and HCC in patients with higher viral loads. HBsAg level was subsequently included to stratify HCC risk in patients with low and intermediate viral loads. Receiver operating characteristic curve analysis showed that combining HBV DNA and HBsAg level better predicts 10-year HCC development as compared to using HBV DNA level alone in the overall cohort (P =. 028). Conclusions. Serum HBsAg level helps stratify HCC risk in patients with intermediate viral loads. Combining HBV DNA and HBsAg levels better predicts HCC risk. ? The Author 2013. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984585959&doi=10.1093%2finfdis%2fjit209&partnerID=40&md5=00b78a07ff437498aa0a32c2338ad927 https://scholars.lib.ntu.edu.tw/handle/123456789/551128 |
ISSN: | 0022-1899 | DOI: | 10.1093/infdis/jit209 http://ntur.lib.ntu.edu.tw//handle/246246/259871 |
SDG/關鍵字: | biological marker; hepatitis B surface antigen; virus DNA; adult; antigen detection; article; cancer risk; controlled study; disease association; female; follow up; human; liver carcinogenesis; liver cell carcinoma; major clinical study; male; priority journal; risk assessment; risk factor; Taiwan; virus load |
顯示於: | 醫學系 |
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