https://scholars.lib.ntu.edu.tw/handle/123456789/551130
標題: | Milder clinical manifestation of scrub typhus in Kinmen, Taiwan | 作者: | TUNG-HUNG SU CHUN-JEN LIU DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2013 | 卷: | 112 | 期: | 4 | 起(迄)頁: | 201-207 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Kinmen, an offshore island of Taiwan, is a popular location for sightseeing and an important entry port between Taiwan and China. Kinmen is also highly endemic for scrub typhus. The authors aimed to investigate the disease characteristics there, which remained largely unknown. Methods: The authors conducted a retrospective study on patients with scrub typhus in Kinmen during 2005-2008. The clinical information was reviewed from medical records for statistical analysis. Results: There were 261 patients with scrub typhus included with a bimodal summer-autumn type of distribution, with most patients (40%) age 20-29 years and a large proportion of patients (26%) older than 60 years. The disease manifestation, laboratory examinations, and treatment outcomes were comparable in summer and autumn. Fever (97%), eschar (93%), and relative bradycardia (67%) were the most common presentations, whereas lymphadenopathy (18%) and skin rash (8%) were infrequent. Elevated liver function, C-reactive protein levels, and low to normal platelet counts were frequent findings. A correct diagnosis was made made in an average 3.7 days after fever or 1.6 visits of medical consultation, and minocycline was prescribed in a timely manner. Most patients had good recovery and only 12 patients (5%) had severe infection with acute renal failure, shock, gastrointestinal bleeding, or respiratory failure; no mortality was found. Older age, longer fever duration, thrombocytopenia, abnormal liver and renal function, hyponatremia, and elevated C-reactive protein levels were significantly associated with severe complications and prolonged treatment duration. Conclusion: A unique summer-autumn type of scrub typhus with milder disease manifestations is identified in Kinmen. The younger patient population, rapid diagnosis, and prompt treatment may be associated with a shortened disease course and lead to a better outcome. ? 2012. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84875597367&doi=10.1016%2fj.jfma.2012.02.002&partnerID=40&md5=7bbdbdfc3db16ec86339e04e2fd381ae https://scholars.lib.ntu.edu.tw/handle/123456789/551130 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2012.02.002 | SDG/關鍵字: | minocycline; acute kidney failure; adult; article; autumn; bradycardia; clinical feature; disease duration; female; fever; gastrointestinal hemorrhage; human; hyponatremia; kidney function; laboratory test; liver function; major clinical study; male; medical record; rash; respiratory failure; retrospective study; scrub typhus; shock; summer; Taiwan; thrombocytopenia; treatment outcome; Adolescent; Adult; Aged; Child; Child, Preschool; Humans; Middle Aged; Scrub Typhus; Seasons |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。