https://scholars.lib.ntu.edu.tw/handle/123456789/551131
標題: | Longitudinal Change of HBsAg in HBeAg-negative Patients with Genotype B or C Infection | 作者: | TUNG-HUNG SU CHUN-JEN LIU TAI-CHUNG TSENG CHEN-HUA LIU HUNG-CHIH YANG CHI-LING CHEN PEI-JER CHEN JIA-HORNG KAO DING-SHINN CHEN |
公開日期: | 2013 | 出版社: | Public Library of Science | 卷: | 8 | 期: | 2 | 來源出版物: | PLoS ONE | 摘要: | Background & Aims: Quantitative HBsAg has been recognized to assist in the management of chronic hepatitis B virus (HBV) infection. However, its role in disease monitoring of HBeAg-negative patients remains unclear. We aimed to investigate the longitudinal HBsAg change in HBeAg-negative carriers with HBV genotype B or C infection. Methods: This is a retrospective cohort study conducted in a university hospital. Treatment-na?ve HBeAg-negative carriers followed for more than 3 years were recruited. Their hepatitis activities were categorized by longitudinal HBV-DNA levels into high viral-load (HVL: HBV-DNA >/ = 2000 IU/mL persistently), low viral-load (LVL: HBV-DNA <2000 IU/mL persistently) and fluctuated viral-load (FVL: HBV-DNA between HVL and LVL). The baseline and end-of-follow-up (EOF) HBsAg levels were quantified for analyses. Results: We recruited 187 patients with a median follow-up of 8 years. LVL patients had a significantly lower HBsAg at baseline and EOF and a significantly greater annualized HBsAg decline compared with the FVL and HVL. The longitudinal HBsAg change was independent of genotype B or C. The lower baseline HBsAg level predicted the HBsAg decline and HBsAg loss, whereas the higher baseline HBV-DNA predicted the hepatitis flare. A baseline HBsAg <50 IU/mL predicted subsequent HBsAg loss with a sensitivity of 82% and specificity of 67%. The annualized HBsAg decline appeared non-linear, and accelerated as the HBsAg level lowered (0.054, 0.091, 0.126 log10 IU/mL in patients with baseline HBsAg >1000, 100-999, <100 IU/mL, respectively, P for trend =. 014). Conclusions: In genotype B or C HBeAg-negative carriers, baseline HBsAg levels correlate with future disease activities and help to predict HBsAg decline or loss. Inactive carriers with lower baseline HBsAg levels have a greater and accelerating HBsAg decline over time, regardless of HBV genotypes. ? 2013 Su et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983723470&doi=10.1371%2fjournal.pone.0055916&partnerID=40&md5=08dea66520432ddae3ce3d56965e05fc https://scholars.lib.ntu.edu.tw/handle/123456789/551131 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0055916 | SDG/關鍵字: | alanine aminotransferase; hepatitis B surface antigen; hepatitis B(e) antigen; virus DNA; adult; alanine aminotransferase blood level; antigen detection; article; cohort analysis; controlled study; disease activity; disease exacerbation; female; follow up; genotype; hepatitis B; human; liver cirrhosis; longitudinal study; major clinical study; male; patient monitoring; retrospective study; sensitivity and specificity; university hospital; virus load |
顯示於: | 醫學系 |
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