https://scholars.lib.ntu.edu.tw/handle/123456789/551213
標題: | Lack of efficacy of troglitazone at clinically achievable concentrations, with or without 9-cis retinoic acid or cytotoxic agents, for hepatocellular carcinoma cell lines | 作者: | Ying-Chun Shen CHIUN HSU Chen J.-Y. ANN-LII CHENG |
公開日期: | 2004 | 卷: | 91 | 期: | 8 | 起(迄)頁: | 1561-1565 | 來源出版物: | British Journal of Cancer | 摘要: | Although the PPARγ agonist troglitazone has been shown to induce growth inhibition of hepatocellular carcinoma (HCC) cells at high concentration, this study indicates troglitazone does not significantly inhibit the growth of HCC cells at clinically achievable concentrations (1-10 μM), and this lack of activity could not be improved by the addition of 9-cis-retinoic acid. Furthermore, no synergistic effect was found between troglitazone and cytotoxic anticancer agents. ? 2004 Cancer Research UK. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-7944226111&doi=10.1038%2fsj.bjc.6602200&partnerID=40&md5=cb95fed136e79d5736c4a616b88d49ce https://scholars.lib.ntu.edu.tw/handle/123456789/551213 |
ISSN: | 0007-0920 | DOI: | 10.1038/sj.bjc.6602200 | SDG/關鍵字: | alitretinoin; cisplatin; cytotoxic agent; gemcitabine; irinotecan; paclitaxel; peroxisome proliferator activated receptor; retinoid X receptor alpha; troglitazone; 2,4 thiazolidinedione derivative; antineoplastic agent; chroman derivative; retinoic acid; troglitazone; article; cancer cell culture; cancer inhibition; cytotoxicity; drug efficacy; human; human cell; liver cell carcinoma; priority journal; protein expression; apoptosis; cell culture; cell division; comparative study; dose response; drug effect; drug potentiation; liver tumor; metabolism; pathology; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Chromans; Dose-Response Relationship, Drug; Drug Synergism; Humans; Liver Neoplasms; Thiazolidinediones; Tretinoin; Tumor Cells, Cultured |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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