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  4. The effects of strontium ranelate in Asian women with postmenopausal osteoporosis
 
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The effects of strontium ranelate in Asian women with postmenopausal osteoporosis

Journal
Calcified Tissue International
Journal Volume
83
Journal Issue
5
Pages
308-314
Date Issued
2008
Author(s)
Hwang J.S.
Chen J.F.
Yang T.S.
Wu D.J.
KEH-SUNG TSAI  
Ho C.
Wu C.H.
Su S.L.
Wang C.J.
Tu S.T.
DOI
10.1007/s00223-008-9180-z
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/551488
Abstract
The aim of this study was to assess the efficacy and safety of strontium ranelate in the treatment of postmenopausal women with osteoporosis in Taiwan. In this 12-month multicenter, randomized, double-blind, placebo-controlled study, 125 women with osteoporosis were randomly given either strontium ranelate 2 g daily or placebo. Lumbar spine, femoral neck, and total-hip bone mineral density (BMD) and biochemical markers of bone turnover were measured; adverse events and tolerability were recorded and assessed. Subjects treated with strontium ranelate showed significant increases in BMD of 5.9% at the lumbar spine, 2.6% at the femoral neck, and 2.7% at the total hip, while the placebo group exhibited no significant change at 12 months. Serum level of a formation marker (bone-specific alkaline phosphatase) was also significantly increased at 6 and 12 months. Thus, although the sample size and the treatment duration of this study could not show its effect of reducing osteoprotic fractures, strontium ranelate showed bone protection effects by increasing BMD and concentrations of a bone formation marker. Safety assessment revealed adverse events were mild and not significantly different from placebo. ? 2008 Springer Science+Business Media, LLC.
Subjects
Bone mineral density; Osteoporosis; Strontium ranelate
SDGs

[SDGs]SDG3

Other Subjects
alkaline phosphatase; placebo; strontium ranelate; abdominal distension; abdominal pain; adult; aged; alopecia; arthralgia; article; Asian; backache; bedtime dosage; bone density; bone turnover; clinical trial; constipation; controlled clinical trial; controlled study; coughing; diarrhea; dizziness; double blind procedure; drug efficacy; drug fatality; drug safety; drug tolerability; evening dosage; female; femur neck; gastrointestinal disease; human; hyperphosphatemia; hyperphosphaturia; insomnia; lumbar spine; major clinical study; metabolic disorder; multicenter study; muscle cramp; nutritional disorder; patient satisfaction; postmenopause osteoporosis; priority journal; randomized controlled trial; side effect; Taiwan; thirst; treatment duration; urinary tract disease
Type
journal article

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