https://scholars.lib.ntu.edu.tw/handle/123456789/551596
標題: | Potential impacts of high-sensitivity creatine kinase-MB on long-term clinical outcomes in patients with stable coronary heart disease | 作者: | YEN-WEN WU Ho, Sing Kong Tseng, Wei-Kung Yeh, Hung-I Leu, Hsin-Bang Yin, Wei-Hsian Lin, Tsung-Hsien Chang, Kuan-Cheng Wang, Ji-Hung CHAU-CHUNG WU Chen, Jaw-Wen |
關鍵字: | BAND ISOENZYME ELEVATION; CK-MB; TROPONIN-I; PROGNOSTIC VALUE; MORTALITY; EVENTS | 公開日期: | 2020 | 出版社: | NATURE PUBLISHING GROUP | 卷: | 10 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | This study aimed to investigate the prognostic value of high-sensitivity creatine kinase-myocardial band or fraction (hsCK-MB) in comparison with other well-established biomarkers including heart type-fatty acid binding protein (H-FABP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with stable coronary heart disease (SCHD). A total of 1,785 patients were enrolled and followed for 36 months. The primary outcome was all-cause mortality. The secondary outcomes included cardiovascular (CV) death, acute myocardial infarction (AMI), angina-related hospitalizations, and hospitalizations for heart failure. The all-cause mortality rate was significantly higher in the high hsCK-MB group compared to the low hsCK-MB group (4.64% vs. 1.88%, p = 0.0026). After adjusting for baseline covariates, there were no significant differences for the secondary outcomes. H-FABP (≥4.226 ng/mL) was the best predictor for all-cause mortality (HR = 2.68, 95% CI = 1.28-5.62, p = 0.009) and CV death (HR = 6.84, 95% CI = 1.89-22.14, p = 0.003). The high NT-proBNP group had a higher AMI-related hospitalization rate (HR = 1.91, 95% CI = 1.00-3.65, p = 0.05). Neither the addition of hsCK-MB to any other markers nor combinations of the three markers improved the prognostic significance of CV outcomes. In conclusion, hsCK-MB was an independent predictor for all-cause mortality but not CV outcomes in patients with SCHD. Combination of hsCK-MB, H-FABP and NT-proBNP failed to improve the prognostic power for all-cause mortality or CV outcomes. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/551596 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-61894-3 | SDG/關鍵字: | biological marker; creatine kinase MB; fatty acid binding protein; adult; coronary artery disease; female; follow up; heart failure; heart infarction; hospitalization; human; male; metabolism; mortality; prognosis; Adult; Biomarkers; Coronary Disease; Creatine Kinase, MB Form; Fatty Acid-Binding Proteins; Female; Follow-Up Studies; Heart Failure; Hospitalization; Humans; Male; Myocardial Infarction; Prognosis |
顯示於: | 醫學教育暨生醫倫理學科所 |
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