https://scholars.lib.ntu.edu.tw/handle/123456789/551597
標題: | Prognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment | 作者: | Li, Yi-Heng Tseng, Wei-Kung Yin, Wei-Hsian FANG-JU LIN YEN-WEN WU Hsieh, I-Chang Lin, Tsung-Hsien Sheu, Wayne Huey-Herng Yeh, Hung-I Chen, Jaw-Wen CHAU-CHUNG WU Taiwanese Secondary Prevention for Patients with AtheRosCLErotic Disease (T-SPARCLE) Registry Investigators |
關鍵字: | HDL CHOLESTEROL; LDL CHOLESTEROL; RESIDUAL RISK; THERAPY; METAANALYSIS; MANAGEMENT; EFFICACY; SAFETY | 公開日期: | 2020 | 出版社: | NATURE RESEARCH | 卷: | 10 | 期: | 1 | 來源出版物: | Scientific Reports | 摘要: | In patients with atherosclerotic cardiovascular disease (ASCVD) under statin treatment, the influence of on-treatment level of high-density lipoprotein cholesterol (HDL-C) on cardiovascular (CV) events is controversial. Statin-treated patients were selected from the Taiwanese Secondary Prevention for patients with AtheRosCLErotic disease (T-SPARCLE) Registry, a multicenter, observational study of adult patients with ASCVD in Taiwan. Low HDL-C was defined as < 40 mg/dL for men and < 50 mg/dL for women. The primary outcome was a composite CV events including CV death, myocardial infarction (MI), stroke or cardiac arrest with resuscitation. A total of 3731 patients (mean age 65.6 years, 75.6% men) were included. Patients with on-treatment low HDL-C (44%, mean HDL-C 34.9 ± 6.8 mg/dL) were younger and with more diabetes and higher body weight. The mean follow-up time was 2.7 years. We used restricted cubic spline curves to examine the potential non-linear association between HDL-C and adverse outcomes. Decreased HDL-C levels were associated with a significantly increased risk of CV events in women (< 49 mg/dL in women) but not in men (< 42 mg/dL in men). However, the protective effect of elevated HDL-C levels was more prominent in men than in women. In ASCVD patients with statin therapy, low on-treatment HDL-C was common in Taiwan and associated with an increased risk of CV events in women. Higher HDL-C levels provided more protective effect in men than in women. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/551597 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-78828-8 | SDG/關鍵字: | high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase inhibitor; aged; blood; cerebrovascular accident; clinical trial; coronary artery disease; female; follow up; heart infarction; human; male; middle aged; multicenter study; prognosis; prospective study; register; risk factor; Aged; Cholesterol, HDL; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Prognosis; Prospective Studies; Registries; Risk Factors; Stroke |
顯示於: | 醫學教育暨生醫倫理學科所 |
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