https://scholars.lib.ntu.edu.tw/handle/123456789/551673
標題: | Predictors of stroke in patients with impaired glucose tolerance: Results from the nateglinide and valsartan in impaired glucose tolerance outcomes research trial | 作者: | Preiss D. Giles T.D. Thomas L.E. Sun J.-L. Haffner S.M. Holman R.R. Standl E. Mazzone T. Rutten G.E. Tognoni G. FU-TIEN CHIANG McMurray J.J.V. Califf R.M. |
關鍵字: | Impaired glucose tolerance; Stroke | 公開日期: | 2013 | 卷: | 44 | 期: | 9 | 起(迄)頁: | 2590-2593 | 來源出版物: | Stroke | 摘要: | Background and Purpose - Risk factors for stroke are well-established in general populations but sparsely studied in individuals with impaired glucose tolerance. Methods - We identified predictors of stroke among participants with impaired glucose tolerance in the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial. Cox proportional-hazard regression models were constructed using baseline variables, including the 2 medications studied, valsartan and nateglinide. Results - Among 9306 participants, 237 experienced a stroke over 6.4 years. Predictors of stroke included classical risk factors such as existing cerebrovascular and coronary heart disease, higher pulse pressure, higher low-density lipoprotein cholesterol, older age, and atrial fibrillation. Other factors, including previous venous thromboembolism, higher waist circumference, lower estimated glomerular filtration rate, lower heart rate, and lower body mass index, provided additional important predictive information, yielding a C-index of 0.72. Glycemic measures were not predictive of stroke. Variables associated with stroke were similar in participants with no prior history of cerebrovascular disease at baseline. Conclusions - The most powerful predictors of stroke in patients with impaired glucose tolerance included a combination of established risk factors and novel variables, such as previous venous thromboembolism and elevated waist circumference, allowing moderately effective identification of high-risk individuals. ? 2013 American Heart Association, Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/551673 | ISSN: | 0039-2499 | DOI: | 10.1161/STROKEAHA.113.001177 | SDG/關鍵字: | low density lipoprotein cholesterol; nateglinide; valsartan; adult; aged; article; body mass; cerebrovascular accident; cholesterol blood level; controlled study; coronary risk; deep vein thrombosis; female; follow up; glomerulus filtration rate; heart atrium fibrillation; heart rate; human; impaired glucose tolerance; ischemic heart disease; lung embolism; major clinical study; male; predictive value; priority journal; pulse pressure; race difference; randomized controlled trial (topic); senescence; transient ischemic attack; waist circumference; impaired glucose tolerance; stroke; Aged; Antihypertensive Agents; Comorbidity; Controlled Clinical Trials as Topic; Cyclohexanes; Drug Therapy, Combination; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Male; Middle Aged; Outcome Assessment (Health Care); Phenylalanine; Predictive Value of Tests; Risk Factors; Stroke; Tetrazoles; Valine |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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