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  1. NTU Scholars
  2. 醫學院
  3. 醫學院附設醫院 (臺大醫院)
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/551744
Title: Plasma Concentration of SCUBE1, a Novel Platelet Protein, Is Elevated in Patients With Acute Coronary Syndrome and Ischemic Stroke
Authors: Dai D.-F.
Thajeb P.
Tu C.-F.
FU-TIEN CHIANG 
Chen C.-H.
Yang R.-B.
Chen J.-J.
Issue Date: 2008
Journal Volume: 51
Journal Issue: 22
Start page/Pages: 2173-2180
Source: Journal of the American College of Cardiology
Abstract: 
Objectives: This study investigates the potential application of plasma SCUBE1 [signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-like domain-containing protein 1] as a biomarker of platelet activation in acute coronary syndrome (ACS) and acute ischemic stroke (AIS). Background: Platelet activation plays a crucial role in ACS and AIS. Platelet stimulation is associated with increased plasma concentration of SCUBE1, a novel platelet-endothelial secreted protein identified in our previous study. Methods: Plasma concentrations of SCUBE1 from 40 ACS and 40 AIS patients were measured by enzyme-linked immunoadsorbent assay and compared with the levels of 40 healthy control subjects and 83 chronic coronary artery disease (CAD) patients. Two-dimensional electrophoresis followed by Western blotting was used to characterize SCUBE1 protein in patients' plasma. Results: Plasma SCUBE1 concentration was virtually undetectable in healthy control subjects and CAD patients, but was significantly higher in ACS and AIS patients (median = 205 and 95.1 ng/ml, respectively, p < 0.01). The increase in plasma SCUBE1 was detectable in the plasma as early as 6 h after the onset of symptoms and remained detectable up to 84 h. Plasma SCUBE1 concentration is an independent predictor of stroke severity based on National Institutes of Health Stroke Scale (β = 3.18, p < 0.001). Furthermore, smaller SCUBE1 fragments were detected in ACS patients' plasma, suggesting that plasma SCUBE1 might subject to a proteolytic regulation under pathological conditions. Conclusions: Plasma SCUBE1 concentration is significantly elevated in ACS and AIS but not CAD patients. Plasma SCUBE1 is a potential biomarker of platelet activation in acute thrombotic disease. ? 2008 American College of Cardiology Foundation.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/551744
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2008.01.060
SDG/Keyword: biological marker; scube1 protein; signal peptide; acute coronary syndrome; adult; article; cerebrovascular accident; coronary artery disease; disease severity; enzyme linked immunosorbent assay; female; human; major clinical study; male; priority journal; protein blood level; protein degradation; rating scale; stroke; symptom; thrombocyte activation; thrombosis; two dimensional electrophoresis; Western blotting; Acute Coronary Syndrome; Biological Markers; Blood Platelets; Brain Ischemia; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Membrane Proteins; Middle Aged; Pilot Projects; Platelet Activation; Platelet Aggregation; Prognosis; Stroke
[SDGs]SDG3
Appears in Collections:醫學院附設醫院 (臺大醫院)

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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