Directly Measured Insulin Resistance and the Assessment of Clustered Cardiovascular Risks in Hypertension
Journal
American Journal of Hypertension
Journal Volume
19
Journal Issue
11
Pages
1118-1124
Date Issued
2006
Author(s)
Lin M.-W.
Hwu C.-M.
Huang Y.-H.
Sheu W.H.-H.
Shih K.-C.
Olshen R.
Chen Y.-D.I.
Curb J.D.
Rodriguez B.
Ho L.-T.
Abstract
Background: The purpose of the study was to use factor analysis to investigate the contribution of a directly measured insulin sensitivity index, steady-state plasma glucose (SSPG) from insulin suppression test (IST), to a clustering of cardiovascular risk factors in hypertensive subjects. Methods: A total of 204 nondiabetic hypertensive patients who received IST for SSPG were included for current analysis. Factor analysis was performed to explore the contribution of SSPG as additional information to a clustering of risk factors in these subjects. Results: In factor analysis, SSPG aggregated with metabolic variables in an obesity-hyperinsulinemia domain that included two factors: one with positive loadings for SSPG, 2-h glucose, and Log 2-h insulin; and the other with positive loadings for body mass index, waist circumference, and fasting glucose. Fasting insulin linked the two factors together and explained 38.3% of the total variance. Systolic and diastolic blood pressures were loaded on a blood pressure domain separately. The third domain consisted of two factors: one with positive loadings for Log triglycerides and negative loading for high-density lipoprotein cholesterol; and the other with positive loadings for Log triglycerides and non-high-density lipoprotein cholesterol. The model loaded without SSPG explained a proportion of the total variance (78.5%) similar to that achieved with the model loaded with SSPG (77.1%). Conclusions: Directly measured insulin sensitivity index SSPG clustered with 2-h glucose and Log 2-h insulin in factor analysis in a cohort consisting entirely of hypertensive subjects. However, the contribution of SSPG as additional information to explain the total variance seems to be insignificant. ? 2006 American Journal of Hypertension, Ltd.
Subjects
Factor analysis; hypertension; insulin sensitivity; obesity
SDGs
Other Subjects
adult; article; cardiovascular risk; controlled study; diastolic blood pressure; factorial analysis; female; glucose blood level; human; hyperinsulinemia; hypertension; insulin resistance; insulin sensitivity; major clinical study; male; priority journal; steady state; systolic blood pressure; waist circumference; Adult; Asian Americans; Asian Continental Ancestry Group; Blood Glucose; Cardiovascular Physiology; Cohort Studies; Factor Analysis, Statistical; Female; Glucose Tolerance Test; Humans; Hypertension; Insulin Resistance; Male; Middle Aged; Obesity; Risk Assessment; Risk Factors
Type
journal article