https://scholars.lib.ntu.edu.tw/handle/123456789/552302
標題: | Prediction of the tuberculosis reinfection proportion from the local incidence | 作者: | JANN-YUAN WANG LI-NA LEE HSIN-CHIH LAI Hsu H.-L. Liaw Y.-S. PO-REN HSUEH PAN-CHYR YANG |
公開日期: | 2007 | 卷: | 196 | 期: | 2 | 起(迄)頁: | 281-288 | 來源出版物: | Journal of Infectious Diseases | 摘要: | Background. Reinfection is a major contributor to tuberculosis (TB). It seems that the higher the local incidence, the higher the proportion of reinfection. Methods. Based on a systematic review of the literature, we established a regression model to predict the reinfection proportion from the local incidence. We then used our local data to verify the algorithm. Results. Of the 23 studies addressing reinfection in recurrent TB, 6 were population based. The reinfection proportion was correlated with the local incidence (reinfection proportion = -29.7 + 36.8 X logIncidence) (95% confidence interval [CI] for coefficient, 15.3-58.3; R2 = 0.849). The reinfection proportion in Taiwan (incidence, 62.4/ 100,000 people) was estimated to be 36% (95% CI, 3%-69%). Of our 49 recurrent patients, 51% had reinfection. Patients with reactivation seemed more likely to have underlying diseases and less likely to be smear positive. The relapse isolates seemed more resistant than the initial isolates. Conclusions. The regression model could possibly predict the TB reinfection proportion from the local incidence. This algorithm is probably helpful in policy making for TB control programs. In areas where TB is endemic, reinfection might be responsible for >50% of TB cases, and aggressive surveillance to detect asymptomatic carriers could be an important strategy for controlling the disease. ? 2007 by the Infectious Diseases Society of America. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/552302 | ISSN: | 0022-1899 | DOI: | 10.1086/518898 | SDG/關鍵字: | bacterial DNA; BCG vaccine; isoniazid; rifampicin; tuberculostatic agent; adult; aged; algorithm; article; bacterium culture; bacterium isolate; comorbidity; DNA fingerprinting; female; human; Human immunodeficiency virus infected patient; infection rate; major clinical study; male; multidrug resistance; Mycobacterium tuberculosis; nonhuman; prediction; priority journal; regression analysis; reinfection; statistical model; systematic review; Taiwan; tuberculosis; DNA Fingerprinting; Forecasting; Humans; Incidence; Models, Statistical; Recurrence; Regression Analysis; Tuberculosis |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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