Fibrin and Platelet-Rich Composition in Retrieved Thrombi Hallmarks Stroke with Active Cancer
Journal
Stroke
Journal Volume
51
Journal Issue
12
Pages
3723
Date Issued
2020-12-01
Author(s)
Abstract
BACKGROUND AND PURPOSE: We aim to investigate whether histopathologic examination of thrombi retrieved from acute ischemic stroke patients undergoing endovascular treatment could distinguish cancer-related stroke from other etiologies. METHODS: Thrombi from patients undergoing endovascular treatment were analyzed. The etiology of stroke was divided into cardioembolism, large artery atherosclerosis, and active cancer groups. All selected thrombi were subjected to hematoxylin and eosin staining. The percentages of fibrin/platelets, red blood cells, and white blood cells within a thrombus were quantified. RESULTS: <0.001). CONCLUSIONS: In thrombi retrieved from patients undergoing endovascular treatment, a high fibrin/platelet composition was a probable indicator of cancer-related stroke.
SDGs
Other Subjects
fibrin; aged; brain ischemia; complication; endovascular surgery; erythrocyte; female; human; leukocyte; male; middle aged; multivariate analysis; neoplasm; pathology; thrombectomy; thrombocyte; thrombosis; ultrastructure; very elderly; Aged; Aged, 80 and over; Blood Platelets; Embolic Stroke; Endovascular Procedures; Erythrocytes; Female; Fibrin; Humans; Ischemic Stroke; Leukocytes; Male; Middle Aged; Multivariate Analysis; Neoplasms; Thrombectomy; Thrombosis; Thrombotic Stroke
Type
journal article