https://scholars.lib.ntu.edu.tw/handle/123456789/553285
標題: | Low prevalence of Helicobacter pylori but high prevalence of cytomegalovirus-associated peptic ulcer disease in AIDS patients: Comparative study of symptomatic subjects evaluated by endoscopy and CD4 counts | 作者: | HAN-MO CHIU MING-SHIANG WU CHIEN-CHING HUNG CHIA-TUNG SHUN Lin J.-T. |
公開日期: | 2004 | 卷: | 19 | 期: | 4 | 起(迄)頁: | 423-428 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background and Aims: The role of Helicobacter pylori infection in gastroduodenal lesions might be different between the general population and AIDS patients. The aim of the present study was to compare the prevalence of H. pylori and cytomegalovirus (CMV) infection in AIDS patients and HIV-negative controls. The impact of CD4 lymphocyte counts on H. pylori and CMV infection in the same subjects was also assessed. Methods: One hundred and fifty-six patients (52 HIV-positive, 104 HIV-negative) with gastrointestinal symptoms were evaluated with upper gastrointestinal endoscopy and biopsy. Comparison of the prevalence of H. pylori and CMV infection was made by dividing AIDS patients into two groups: those with CD4 counts >100/mm3 and those with CD4 counts <100/mm3, and ulcer and non-ulcer patients. Results: In comparison with HIV-negative controls, AIDS patients had a lower prevalence of H. pylori infection (P < 0.0001) but a higher prevalence of CMV infection (P < 0.0001). Cytomegalovirus infection was frequently found in AIDS patients with CD4 count <100/mm3, in comparison with those with a CD4 count >100/mm3. In AIDS patients, CMV was more frequently detected in subjects with peptic ulcers (P = 0.0125). Conversely, the prevalence of H. pylori infection in AIDS patients was not different between those with and without peptic ulcers. Conclusions: The low prevalence of H. pylori infection and peptic ulcer in AIDS patients suggests a different role of H. pylori infection in peptic ulcer or even a different mechanism of peptic ulcerogenesis in HIV-positive subjects. Cytomegalovirus, rather than H. pylori, may be the main causative pathogen of peptic ulcers in AIDS patients. ? 2004 Blackwell Publishing Asia Pty Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/553285 | ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.2003.03278.x | SDG/關鍵字: | CD4 antigen; acquired immune deficiency syndrome; adult; aged; article; comparative study; controlled study; Cytomegalovirus; cytomegalovirus infection; disease association; endoscopy; female; gastrointestinal biopsy; gastrointestinal endoscopy; gastrointestinal symptom; Helicobacter infection; Helicobacter pylori; human; Human immunodeficiency virus; lymphocyte count; major clinical study; male; medical assessment; patient; peptic ulcer; prevalence; priority journal; symptom; upper gastrointestinal tract |
顯示於: | 法醫學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。