Circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM 1) in head and neck cancer
Journal
British Journal of Cancer
Journal Volume
79
Journal Issue
2
Pages
360-362
Date Issued
1999
Author(s)
Abstract
The sera from patients with nasopharyngeal carcinoma (n = 30), oral carcinoma (n = 22) and laryngeal carcinoma (n = 22) was extracted before treatment. The concentration of circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) was measured by enzyme-linked immunoassay and compared with those from normal subjects (n = 20). The concentration of circulating ICAM-1, E-selectin and VCAM-1 was significantly increased in nasopharyngeal carcinoma. Correspondingly, VCAM-1 and E-selectin were significantly increased in laryngeal carcinoma, whereas only E-selectin was elevated in oral carcinoma. The concentrations of these adhesion molecules did not significantly differ with respect to the early and late stages of these carcinomas. Elevated levels of soluble adhesion molecules in the sera of cancer patients at three different head and neck regions, although appearing to be implicated in these tumour formations, may be unrelated to tumour progression.
SDGs
Other Subjects
endothelial leukocyte adhesion molecule 1; intercellular adhesion molecule 1; vascular cell adhesion molecule 1; analytical equipment; article; blood level; controlled study; enzyme linked immunosorbent assay; head and neck cancer; human; larynx carcinoma; major clinical study; mouth carcinoma; nasopharynx carcinoma; priority journal
Type
journal article