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  1. NTU Scholars
  2. 醫學院
  3. 醫學院附設醫院 (臺大醫院)
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/554016
Title: Computer-aided US diagnosis of breast lesions by using cell-based contour grouping
Authors: Cheng J.-Z.
Chou Y.-H.
Huang C.-S.
YEUN-CHUNG CHANG 
Tiu C.-M.
Chen K.-W.
Chen C.-M.
Issue Date: 2010
Journal Volume: 255
Journal Issue: 3
Start page/Pages: 746-754
Source: Radiology
Abstract: 
Purpose: To develop a computer-aided diagnostic algorithm with automatic boundary delineation for differential diagnosis of benign and malignant breast lesions at ultrasonography (US) and investigate the effect of boundary quality on the performance of a computer-aided diagnostic algorithm. Materials and Methods: This was an institutional review board-approved retrospective study with waiver of informed consent. A cellbased contour grouping (CBCG) segmentation algorithm was used to delineate the lesion boundaries automatically. Seven morphologic features were extracted. The classifier was a logistic regression function. Five hundred twenty breast US scans were obtained from 520 subjects (age range, 15-89 years), including 275 benign (mean size, 15 mm; range, 5-35 mm) and 245 malignant (mean size, 18 mm; range, 8-29 mm) lesions. The newly developed computer-aided diagnostic algorithm was evaluated on the basis of boundary quality and differentiation performance. The segmentation algorithms and features in two conventional computer-aided diagnostic algorithms were used for comparative study. Results: The CBCG-generated boundaries were shown to be comparable with the manually delineated boundaries. The area under the receiver operating characteristic curve (AUC) and differentiation accuracy were 0.968 ± 0.010 and 93.1% ± 0.7, respectively, for all 520 breast lesions. At the 5% significance level, the newly developed algorithm was shown to be superior to the use of the boundaries and features of the two conventional computer-aided diagnostic algorithms in terms of AUC (0.974 ± 0.007 versus 0.890 ± 0.008 and 0.788 ± 0.024, respectively). Conclusion: The newly developed computer-aided diagnostic algorithm that used a CBCG segmentation method to measure boundaries achieved a high differentiation performance. ? RSNA, 2010.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/554016
ISSN: 0033-8419
DOI: 10.1148/radiol.09090001
metadata.dc.subject.other: adolescent; adult; aged; algorithm; article; breast cancer; breast disease; breast lesion; cell based contour grouping; computer assisted diagnosis; differential diagnosis; echography; female; human; image quality; intermethod comparison; major clinical study; priority journal; tumor volume; Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Breast Diseases; Diagnosis, Computer-Assisted; Diagnosis, Differential; Female; Humans; Logistic Models; Middle Aged; Retrospective Studies; ROC Curve; Ultrasonography, Mammary
[SDGs]SDG3
Appears in Collections:醫學院附設醫院 (臺大醫院)

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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