https://scholars.lib.ntu.edu.tw/handle/123456789/556784
標題: | Spatial Dependency of Tuberculosis Incidence in Taiwan | 作者: | Ng I.-C. Wen T.-H. JANN-YUAN WANG CHI-TAI FANG |
公開日期: | 2012 | 卷: | 7 | 期: | 11 | 來源出版物: | PLoS ONE | 摘要: | Tuberculosis (TB) disease can be caused by either recent transmission from infectious patients or reactivation of remote latent infection. Spatial dependency (correlation between nearby geographic areas) in tuberculosis incidence is a signature for chains of recent transmission with geographic diffusion. To understand the contribution of recent transmission in the TB endemic in Taiwan, where reactivation has been assumed to be the predominant mode of pathogenesis, we used spatial regression analysis to examine whether there was spatial dependency between the TB incidence in each township and in its neighbors. A total of 90,661 TB cases from 349 townships in 2003-2008 were included in this analysis. After adjusting for the effects of confounding socioeconomic variables, including the percentages of aboriginals and average household income, the results show that the spatial lag parameter remains positively significant (0.43, p<0.001), which indicates that the TB incidences of neighboring townships had an effect on the TB incidence in each township. Townships with substantial spatial spillover effects were mainly located in the northern, western and eastern parts of Taiwan. Spatial dependency implies that recent transmission plays a significant role in the pathogenesis of TB in Taiwan. Therefore, in addition to the current focus on improving the cure rate under directly observed therapy programs, more resource need to be allocated to active case finding in order to break the chain of transmission. ? 2012 Ng et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870624680&doi=10.1371%2fjournal.pone.0050740&partnerID=40&md5=2aa465a73024f452dbe1c421bf0fa07d https://scholars.lib.ntu.edu.tw/handle/123456789/556784 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0050740 | SDG/關鍵字: | Aborigine; adult; aged; article; city; controlled study; disease transmission; educational status; endemic disease; household income; human; incidence; lung tuberculosis; marriage; pathogenesis; population density; regression analysis; socioeconomics; spatial regression analysis; Taiwan; worker; Analysis of Variance; Humans; Incidence; Middle Aged; Regression Analysis; Spatial Analysis; Spatio-Temporal Analysis; Taiwan; Tuberculosis, Pulmonary |
顯示於: | 流行病學與預防醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。