Surgical complications and outcome of living related liver transplantation
Journal
Transplantation Proceedings
Journal Volume
36
Journal Issue
8
Pages
2249-2251
Date Issued
2004
Author(s)
Ko W.-J.
Lai M.-Y.
Lin M.-H.
Lin H.-Y.
Abstract
Living donor liver transplantation (LDLT) is now widely performed for patients to resolve the critical shortage of organs from cadavers. Despite rapid implementation and expansion of the procedure, both outcome and complication analyses of LDLT are still incomplete. To analyze the outcome of LDLT, with particular reference to complications of those in need of surgical or radiological intervention. Forty-eight LDLTs performed at National Taiwan University Hospital between December 1997 and April 2003 were reviewed retrospectively. Forty-two (87.5%) patients survived the operation. The 1-year graft and patient survival rate was 81.5%. Seventeen of the 48 LDLT patients had at least one postoperative complication, which needed surgical or radiological intervention. The complications included bile leakage (n = 3), biliary stricture (n = 4), internal bleeding (n = 7), intra-abdominal abscess (n = 2), liver abscess (n = 1), hepatic artery thrombosis (n = 2), duodenal ulcer bleeding (n = 1), jejunal perforation (n = 1), adhesion ileus (n = 1), and intracranial hemorrhage (n = 1). Nine of the 17 patients with complications died. In contrast, only 2 of the other 31 patients died. Seven of the mortalities were related to the complications. All survivors received only one definite intervention early after the complications were diagnosed. However, the others received an average of 1.71 ± 0.95 (0 to 3) interventions. Complications requiring surgical or radiological treatment caused major mortality of LDLT. Early and definite treatment of these complications is important to improve the patient's outcome.
SDGs
Other Subjects
cyclosporin A; hepatitis B antibody; lamivudine; prednisolone; tacrolimus; abdominal abscess; artery thrombosis; bile leakage; bleeding; brain hemorrhage; cause of death; conference paper; duodenum bleeding; graft rejection; graft survival; hepatic artery; hepatitis B; human; intestine perforation; liver abscess; liver transplantation; living donor; living related liver transplantation; postoperative complication; postoperative period; priority journal; relative; survival rate; Follow-Up Studies; Humans; Liver Transplantation; Living Donors; Postoperative Complications; Retrospective Studies; Survival Analysis; Time Factors; Treatment Outcome
Type
conference paper