https://scholars.lib.ntu.edu.tw/handle/123456789/557546
標題: | Serum 2',5'-ogligoadenylate synthase concentrations in acute and chronic hepatitis C | 作者: | PEI-MING YANG JIN-TOWN WANG BOR-LUEN CHIANG Lai M.-Y. DING-SHINN CHEN |
公開日期: | 1997 | 卷: | 96 | 期: | 5 | 起(迄)頁: | 314-319 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | To clarify the role of in vivo interferon activation in the recovery from acute hepatitis C and in the prediction of responses to interferon-α treatment in chronic hepatitis C, we measured concentrations of 2',5'- oligoadenylate synthetase in the serum of 14 patients with well-documented acute post-transfusion hepatitis C and 40 patients with histologically confirmed chronic hepatitis C. In the latter group, 16 received interferon- α treatment, while no specific treatment was given to patients with acute hepatitis C. Serum activity of 2',5'-oligoadenylate synthetase was measured in duplicate by radioimmunoassay. Four out of the 14 patients with acute hepatitis C recovered, and hepatitis in the remaining 10 became chronic. Serum 2',5'-oligoadenylate synthetase concentration in the acute stage of hepatitis was above 200 pmol/dL in all four patients who recovered and in only two of the remaining 10 patients (p < 0.02, Fisher's exact test). The 16 chronic hepatitis C patients who received interferon-α treatment were classified into sustained responders, relapsed responders and nonresponders, as judged by their responses to the treatment. Among the three groups, there was no significant difference in the mean concentrations of 2',5'- oligoadenylate synthetase either before the treatment or in the peak concentrations during the treatment. We conclude that activation of in vivo interferon in the acute stage favors recovery from acute hepatitis C, and 2',5'-oligoadenylate synthetase concentration cannot predict the responses to interferon-α treatment in patients with chronic hepatitis C. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030938634&partnerID=40&md5=97f855f46628a20e8f5c173325dda79b https://scholars.lib.ntu.edu.tw/handle/123456789/557546 |
ISSN: | 0929-6646 | SDG/關鍵字: | 2',5' oligoadenylate synthetase; alpha interferon; recombinant alpha2b interferon; adult; article; chronic disease; controlled study; disease association; drug half life; enzyme activation; enzyme activity; hepatitis c; human; immunomodulation; infection risk; major clinical study; prediction; radioimmunoassay; risk management; 2',5'-Oligoadenylate Synthetase; Acute Disease; Antiviral Agents; Chronic Disease; Hepatitis C; Humans; Interferon Alfa-2b; Radioimmunoassay |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。