https://scholars.lib.ntu.edu.tw/handle/123456789/557551
標題: | Superinfection by homotypic virus in hepatitis C virus carriers: Studies on patients with post-transfusion hepatitis | 作者: | JIA-HORNG KAO PEI-JER CHEN JANN-TAY WANG PEI-MING YANG Lai M.Y. Wang T.H. DING-SHINN CHEN |
公開日期: | 1996 | 卷: | 50 | 期: | 4 | 起(迄)頁: | 303-308 | 來源出版物: | Journal of Medical Virology | 摘要: | Although heterotypic superinfection and mixed infections of hepatitis C virus (HCV) may be possible for hepatitis flares in chronic hepatitis C, the possibility of homotypic HCV superinfection in HCV carriers with post-transfusion hepatitis has not been explored. Six HCV carriers with post-transfusion non-A, non-B hepatitis found in a prospective study of post-transfusion hepatitis were included. Serum samples before transfusion and during hepatitis were selected to determine genotypes of HCV and nucleotide sequences of the hypervariable region (HVR). The genotypes identified before and after transfusion were concordant in all. There were four with type 1b and one each with type 2a and type 2b. Amplified nucleotide sequences of the HVR before transfusion and during hepatitis were compared in four patients, and a >95% homology was observed in three, suggesting persistence of original viruses. In contrast, only a 51% homogeneity was seen in a given patient, suggesting a homotypic HCV superinfection. Phylogenetic tree analysis validated further these findings. This study implies that HCV carriers can be reinfected by homotypic HCV, and this may contribute to hepatitis flares in chronic hepatitis C. These findings also confirm a weak or inadequate protective immunity in HCV infection and justify protection from reinfection of HCV of patients with chronic hepatitis C. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029837003&doi=10.1002%2f%28SICI%291096-9071%28199612%2950%3a4%3c303%3a%3aAID-JMV4%3e3.0.CO%3b2-C&partnerID=40&md5=c4f1f20ba379e87eadb71e175255150e https://scholars.lib.ntu.edu.tw/handle/123456789/557551 |
ISSN: | 0146-6615 | DOI: | 10.1002/(SICI)1096-9071(199612)50:4<303 | SDG/關鍵字: | adult; article; blood transfusion; clinical article; clinical trial; female; genotype; hepatitis c; hepatitis c virus; human; male; reverse transcription polymerase chain reaction; superinfection; Adult; Base Sequence; Blood Transfusion; Carrier State; Chronic Disease; DNA, Viral; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Male; Middle Aged; Molecular Sequence Data; Phylogeny; Polymerase Chain Reaction; Prospective Studies; Superinfection; Hepatitis C virus; Non-A, non-B hepatitis virus |
顯示於: | 醫學系 |
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