|Title:||Chronic hepatitis C without anti-hepatitis C antibodies by second-generation assay: A clinicopathologic study and demonstration of the usefulness of a third-generation assay||Authors:||JIA-HORNG KAO
|Issue Date:||1996||Publisher:||Springer New York LLC||Journal Volume:||41||Journal Issue:||1||Start page/Pages:||161-165||Source:||Digestive Diseases and Sciences||Abstract:||
To study the clinicopathologic features of hepatitis C viremic patients negative for hepatitis C antibodies (anti-HCV) by current second-generation assay, we categorized 139 consecutive histologically verified patients with chronic non-A, non-B hepatitis into three groups: 121 (87%) were positive for second-generation anti-HCV (group A); 10 (7%) were negative for second-generation anti-HCV but positive for HCV RNA (group B); and 8 (6%) were negative for both antibodies and viremia (group C). Six (60%) of group B patients could be further detected by a new third-generation assay, but none of group C patients was third-generation anti-HCV-positive. The demographic features, mean peak serum alanine aminotransferase levels, HCV genotype distribution, and histologic-changes were comparable among the three groups. The study indicates that most patients with chronic hepatitis C in Taiwan could be identified by current second-generation assay, and viremic but antibody seronegative patients were clinicopathologically similar to the seropositives. Most patients of the latter group could be diagnosed by a third-generation assay, indicating the usefulness of this assay.
|ISSN:||0163-2116||DOI:||10.1007/BF02208599||SDG/Keyword:||hepatitis C antibody; virus RNA; adult; article; chronic hepatitis; controlled study; diagnostic test; female; hepatitis C; human; major clinical study; male; polymerase chain reaction; priority journal; viremia
|Appears in Collections:||醫學系|
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